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Modulation of carcliac function by L-Arginine NO system

Research Project

Project/Area Number 08670751
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTohoku University

Principal Investigator

IKEDA Jun  Tohoku University, hospital, Research associate, 医学部・附属病院, 助手 (90211028)

Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsSympathetic Nervous System / LV function / L-Arginine NO System / NOS inhibiter / NO合成酵素阻害剤
Research Abstract

In this project, we examined to clarify whether the inhibition of L-arginine NO system augments the positive inotropic response on the left ventricle to direct stimulation of the sympathetic nervous system in vivo.
We performed electrical stimulation on left stellate ganglion (LSG) for 1min in submaximal (5V-2.5, 5 and 10Hz) and supramaximal intensities(10V-l0Hz) to twelve anesthetized and vagotomized dogs. Next, in the same dogs, Nw-nitro L-arginine methylester (L-NAME) at 0.1mg was infused into the left anterior descending (LAD) coronary artery, and the LSG stimulation was repeated in the same protocol. Finally, L-arginine at 100mg was infused into the LAD artery, and the same LSG stimulation was repeated. We applied the maximum of the first derivative of left ventricular pressure (LVmax dP/dt) as the index of the myocardial contraction. We measured the plasma epinephrine and norepinephrine concentrations in the coronary sinus (Ecs, NEcs) at 5V-2.5Hz before and after L-NAME treatment in five of twelve dogs.
L-NAME treatment significantly augmented the inotropic response on left ventricle (percent change in the LVmax dP/dt) to the LSG submaximal stimulation trains from 164*13 to.212*21 (p<0.03), from 187*15 to 234*25 (p<0.05) and from 220*19 to 28033% (p<0.05), respectively. This response reversed by L-arginine treatment. However, the inotropic response to the supramaximal stimulation train did not change after L-NAME and L-arginine treatment. L-NAME significantly increased NEcs from 0.69*0.41 to 1.00*0.52ng/ml while this did not change Ecs.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Takita. T, Ikeda. J,ほか: "Nitric Oxide Moclulates Sympathetic Control of left ventricular. Contraction in vivo in the dog" Journal of the Autonamic Nerrous System. 71. 69-74 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takita T,Ikeda J.et al: "Nitric Oxide Modulates Sympathetic Control of Left Ventricular Contraction in vivo in the Dog" Journal of the Autonomic Nervous System. Vol.71. 69-74 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T.Takita, J.Ikedaら: "Nitric Oxide Modulates Sympathctic Control of Left ventricular contraction in vivo in the dog" Journal of the Autonanic Neurons System. 71巻. 69-74 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Takita, J.Ikeda, et al.: "Nitric Oxide Modulates Sympatictic Control on Left ventriclar Contraction in vive" Journal of the Autonomic IVrvons System. (in press). (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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