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Mechanism of exertional dyspnea in heart failure patients

Research Project

Project/Area Number 08670772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KOIKE Akira  Tokyo Medical and Dental University, Department of Medicine, Assistant professor, 医学部, 助手 (60234655)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsHeart failure / Exercise test / Ventilation / Potassium
Research Abstract

It has been suggested that the serum potassium concentration plays an important role in determining the increased ventilation during exercise. The present study was conducted to investigate the mechanisms of the increased ventilation during exercise, focusing the role of serum potassium in the ventilatory response to exercise, in patients with chronic heart failure. Thirteen patients performed 6 minutes of moderate-intensity constant work-rate exercise before and after oral administration of slow-release potassium chloride for 4 weeks. In 8 patients, serum potassium concentration was increased by more than 10 % after administration of potassium chloride. In these patients, serum potassium concentration was significantly increased from 3.58(]SY.+-。[)0.33 to 4.23(]SY.+-。[)0.29 mEq/l at rest and from 3.83(]SY.+-。[)0.43 to 4.70(]SY.+-。[)0.36 mEq/l at the end of exercise. However, minute ventilation at rest was 12.0(]SY.+-。[)2.6 L/min before and 12.3(]SY.+-。[)1.8 L/min after administration of potassium, showing no significant difference. Minute ventilation at the end of exercise was 43.5(]SY.+-。[)8.1 L/min after administration of potassium and did not differ from that before administration (44.5(]SY.+-。[)9.5 L/min). From the present study, it was strongly suggested that the serum potassium concentration is not an important factor in determining ventilatory response during exercise in patients with chronic heart failure.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Akira Koike: "Relation between oxygen uptake and carbon dioxide output during constant work-rate exercise in patients with mild congestive heart failure." Am J Cardiol. 77. 602-605 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akihiko Nogami: "Time-versus frequency-domain analysis in predicting cycle length of inducible ventricular tachycardia after myocardial infarction." PACE. 19. 314-324 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hiromasa Adachi: "Does appropriate endurance exercise training improve cardiac function in patients with prior myocardial infarction?" Eur Heart J. 17. 1511-1521 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akira Koike: "Cardiopulmonary exercise testing" Cardiologist. 1. 359-361 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Karlman Wasserman: "Lung function and exercise gas exchange in chronic heart failure." Circulation. 96. 2221-2227 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Noritaka Shimizu: "Cardiomyopathy in a case of Crow-Fukase syndrome" Jpn Heart J. 38. 877-880 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hideomi Fujiwara: "Effects and evaluation of endurance exercise training after successful PTCA in patients with acute myocardial infarction" Jpn J Appl Physiol. 27. 89-93 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akira Koike: "Cardiopulmonary responses during the onset of exercise" J Adaptation Med. 1. 82-88 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akira Koike: "Delayd kinetics of oxygen uptake during recovery after exercise in cardiac patients." Med Sci Sports Exerc. 30. 185-189 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akira Koike: "Effects of isosorbide dinitrate on oxygen uptake kinetics in cardiac patients." Med Sci Sports Exerc. 30. 190-194 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akira Koike: Exercise Gas Exchange in Heart Disease.Futura Publishing Company Inc., 15 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Askira Koike: "Relation between oxygen updore and cerbon d osid output dunag anstant work rate exercise in patients with mild ungestive heart failure" Am J Cardiol. 77. 602-605 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akihiko Nogami: "Time-versus frequoncy-domexn analysis in predicting cycle length of inducible ventncnlar to chycardia after myocardial infarction" Pace. 19. 314-324 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiromasa Adachi: "Does appropriate enduromce exercise rraining improve cardiac fumction in patients with prior myocarclial infarction?" Eur Heart J. 17. 1511-1521 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小池 朗: "心肺運動負荷試験" Cardiclogist. 1. 359-361 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Karlmen Wasserman: "Lung funetion and excrcise gas exchange in chronic heart failure" Cirunlation. 96. 2221-2227 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Noritaka Shimizu: "Cardiomyorathy in a case of Crow-Fukase synelrome" Jpn Heart J. 38. 877-880 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小池 朗: "運動負荷時の呼吸・循環の応答" 遍応医学. 1. 82-88 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 藤原 秀臣: "急性心筋梗塞の待機的PTCA成功例における回復期運動床法の効果とその判定" 日本離床生理学会雑誌. 27. 89-93 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akira Koike: "Delayed kinetics of oxygen uptake during recovery ofter exeroise in cardiae patients" Med Sci Sports Exerc. 30. 185-189 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akira Koike: "Effects of isosorbide dinitrate on oxygen uptake kinetics in cordiac patients" Med Sci Sports Exprc. 30. 190-194 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akira Koike: "Exeruse Gas Exchange in Heart Diseuse" Futura Publishing Copany Inc, 15 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akira Koike: "Relation between oxygen uptake and carbon dioxide output during constant work rate exeruse in patients with mild wngestive heart failure" Am J Cardiol. 77. 602-605 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hiromasa Adachi: "Does appropriate erelurance exeruse training improve cardiac function in patients with prior myocardial infarction?" Eur Heart J. 17. 1511-1521 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小池 朗: "心肺運動負荷試験" Cardiologist. 1. 359-361 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akira Koike: "Effects of isasorbide dinitrate on oxygen uptake kinetics in pationts with cormary artery disease" Med Sci Sports Exerc. (発表予定). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akira Koike: "Exeruse Gas Exchange in Heart Disease" Futura Publishing Company,Inc., 109-123 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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