| Project/Area Number |
08670796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kagawa Medical University |
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Principal Investigator |
MASUGATA Hisashi Kagawa Medical University, Second Department of Internal Medicine, Research Associate, 医学部・附属病院, 助手 (70263910)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Seiji Kagawa Medical University, Second Department of Internal Medicine, Research Asso, 医学部・附属病院, 助手 (60253267)
NOZAKI Shiro Kagawa Medical University, Second Department of Internal Medicine, Research Asso, 医学部・附属病院, 助手 (80243773)
MIZUSHIGE Katsufumi Kagawa Medical University, Second Department of Internal Medicine, Assistant Pro, 医学部・附属病院, 講師 (90166009)
SENDA Shoichi Kagawa Medical University, Second Department of Internal Medicine, Research Asso, 医学部・附属病院, 教授 (30145049)
MATSUO Hirohide Kagawa Medical University, Second Department of Internal Medicine, Professor, 医学部, 教授 (90028514)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | M-mode intravascular ultrasound / Aging / Arterial wall / Visco-elasticity / Coronary artery / Plaque / Elastic fiber / Collagen fiber |
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| Research Abstract |
1.Development of M-mode intravascular ultrasound imaging system :
In order to depict arbitrary directional M-mode images of arterial wall using intravascular ultrasound, we developed an omni-directional M-mode intravascular ultrasound system. A 1mm x 1mm ultrasound transducer with 30 MHz center frequency, is mounted at the tip of catheter, and the M-mode arterial wall images are depicted in arbitrary direction. The resolution is 0.15mm. In addition, we can gain almost real time two-dimensional images of the arterial wall by the system.
Assessment of stiffness of human arterial wall by M-mode intravascular ultrasound :
We evaluated local arterial wall elastic property based on the relationship between instantaneous arterial wall thickness during cardiac cycle measured by M-mode intravascular ultrasound and simultaneous intraluminal pressure. In human, arterial stiffness increased after branching of the renal artery and increased greatly towards the periphery. In addition, human arterial wall stiffness increased with advancing age. These findings were related to an increase of wall thickness/luminal ratio, which may reflect a morphological change in the artery associated with the progression of arteriosclerosis.
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