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Endothelin Research and Atherosclerosis

Research Project

Project/Area Number 08670817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka City University

Principal Investigator

KOHNO Masakazu  Osaka City University, Medical School, Assistant Professor, 医学部, 講師 (20153489)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Junichi  Osaka City University, Medical School, Professor, 医学部, 教授 (60275245)
YASUNARI Kenichi  Osaka City University, Medical School, Assistant, 医学部, 助手 (90231646)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Keywordsendothelin / vascular smooth muscle cell / proliferation / migration / coronary atherosclerosis / endothelin receptor
Research Abstract

Enidothelin (ET-1) is a vasoconstrictive and growth-promoting peptide that was firstly isolated from porcine vascular endothelial cells. Plasma ET-1 levels were shown to be increased in patients with symptomatic atherosclerotic vascular disease and hyperlipidemia. In the current study, we found that lysophosphatidylcholine, a prominent component of oxidized LDL, induces human coronary artery SMC migration and this lyso-PC-induced migration can be further induced by ET-1. Er_A receptor antagonist inhibited this enhancement by ET-1. We also found that lyso-PC stimulated ET-1 production in curltured human coronary artery SMC.ET-1 may recruit medial SMC during the process of coronary atherosclerosis in concert with oxidized LDL (lyso-PC) in vascular tissues. The conversion of phosphatidyicholine of LDL into lyso-PC during oxidized modification and ET-1 in atherosclerotic arterial wall may contribute to coronary atherogenesis. especiafly to the initial step of this disorder. Therefore, interventions that prevent this conversation in vivo and ET antagonism may be predicted to act to reduce coronary artery medial SMC_s into the intima in various pathophysiological settings.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Masakazu Kohno: "Induction by lysophosphatidylcholin, a major phospholid conponent of atherotenic lipoproteins,of human coranarv artery smooth mascle cell niigratior" Circulation. 98(4). 353-359 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masakazu Kohno: "Effect of the endothelin family of peptides on human coronary artery smooth-muscle cell migration" Journal of Cardiovascular Pharmacology. 31(suppl.1). S84-S89 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koji Yokokawa: "Heparin suppresses cyclosporine-induced endothelin-1 synthesis in rat endothelial cells" Journal of Cardiovascular Pharmacology. 31(suppl.1). S460-S463 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mieko Minami: "Supression of endothelin-3-induced nitric oxide synthesis by triglyceride in human endothelial cells" Journal of Cardiovascular Pharmacology. 31(suppl.1). S467-S469 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 河野 雅和: "レニン・アンジオテンシン系と高血圧-レニン・アンジオテンシン系とエンドセリン-" 先端医学社, 197-201 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] T Hanehira, M Kohno, J Yoshikawa: "Endothelin production in cultured vascular smooth muscle cells - Modulation by the ANP-BNP-CNP system-" Metabolism. 46. 487-493 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M Kohno, K Yokokawa, K Yasunari, H Kano, M Minami, M Ueda, Y Tatsumi, J Yoshikawa: "Renoprotective effects of a combined endothelin type A/ type B receptor antagonist in experimental malignant hypertension" Metabolism. 46. 1032-1038 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M Kohno, K Yokokawa, H Kano, K Yasunari, M Minami, T Hanehira, J Yoshikawa: "Adrenomedullin is a potent inhibitor of angiotensin II-induced migration of human coronary artery smooth muscle cells" Hypertension. 29. 1309-1313 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M Kohno, K Yokokawa, K Yasunari, H Kano, M Minami, M Ueda, J Yoshikawa: "Effect of natriuretic peptide family on the oxidized LDL-induced migration of human coronary artery smooth muscle cells" Circulation Research. 81. 585-590 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K Yasunari, M Kohno, H Kano, K Yokokawa, M Minami, J Yoshikawa: "Mechanisms of action of troglitazone in the prevention of high glucose-induced migration and proliferation of cultured coronary smooth muscle cells" Circulation Research. 81. 953-962 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M Kohno, K Yokokawa, K Yasunari, M Minami, H Kano, T Hanehira, J Yoshikawa: "Induction by lysophosphatidylcholine, a major phospholipid component of atherogenic lipoproteins, of human coronary artery smooth muscle cell migration" Circulation. 98 (4). 353-359 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M Kohno, K Yokokawa, K Yasunari, H Kano, M Minami, J Yoshikawa: "Effect of the endothelin family of peptides on human coronary artery smooth-muscle cell migration" Journal of Cardiovascular Pharmacology. 31 (suppl.1). S84-S89 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K Yokokawa, M Kohno, M Minami, K Yasunari, AK Mandal J Yoshikawa: "Heparin suppresses cyclosporine-induced endothelin-1 synthesis in rat endothelial cells" Journal of Cardiovascular Pharmacology. 31 (suppl.1). S460-S463 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M Minami, K Yokokawa, M Kohno, K Yasunari, J Yoshikawa: "Suppression of endothelin-3-induced nitric oxide synthesis by triglyceride in human endotherial cells" Journal of Cardiovascular Pharmacology. 31 (suppl.1). S467-S463 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masakazu Kohno: "Induction by lysephesphatidyl chelin,a major phospholid component of atherogenic lipoproteins,of human coronary artery smooth muscle cell migration" Circulation. 98(4). 353-359 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masakazu Kohno: "Effect of the endothelin family of peptides on human coronary artery smooth-muscle cell migration" Journal of Cardiovascular Pharmacology. 31 Suppl.1. S84-S89 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koji Yokokawa: "Heparin suppresses cyclosporine-induced endothelin-1 synthesis in rat endothelial cells" Journal of Cardiovascular Pharmacology. 31 Suppl.1. S460-S463 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mieko Minami: "Supression of endothelin-3-induced nitric oxide synthesis by triglyceride in human endothelial cells" Journal of Cardiovascular Pharmacology. 31 Suppl.1. S467-S469 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 河野 雅和: "レニン・アンジオテンシン系と高血圧-レニン・アンジオテンシン系とエンドセリン-" 先端医学社, 197-201 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takao Hanehira: "Endothelin production in cultured vascular smooth muscle cells -Modulation by the ANP-BNP-CNP system-" Metabolism. 46. 487-493 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masakazu Kohno: "Renoprorective effects of a combined endothelin type A / type B receptor antagonist in experimental malignant hypertension" Metabolism. 46. 1032-1038 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masakazu Kohno: "Adrenomedullin is a potent inhibitor of angiotensin II-induced migration of human coronary artery smooth muscle cells" Hypertension. 29. 1309-1313 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masakazu Kohno: "Effect of natriuretic peptide family on the oxidezed LDL-induced migration of human coronary artery smooth muscle cells" Circulation Research. 81. 585-590 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kenichi Yasunari: "Mechanisms of action of troglitazone in the prevention of high glucose-induced migration and proliferation of cultured coronary smooth muscle cells" Circulation Research. 81. 953-962 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masakazu Kohno: "Induction by lysophosphatidylcholine,a Major Phospholipid component of atherogenic lipoproteins,of human coronary artery smooth muscle cell migration" Circulation(発表予定).

    • Related Report
      1997 Annual Research Report
  • [Publications] 河野雅和: "高血圧の基礎から臨床まで-1996年第16回高血圧シンポジウム-" 診断と治療社, 9(20-28) (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masakazu Kohno: "Interaction of adrenomedullin and platelet-derived growth factor on rat mesangial cell production of endothelin" Hypertension. 27・3 (Pt2). 663-667 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masakazu Kohno: "Renoprotective effects of a combined endothelin type A/type B receptor antagonist in experimental malignant hypertension" Metabolism. (発表予定).

    • Related Report
      1996 Annual Research Report
  • [Publications] Takao Hanehira: "Endothelin production in cultured vascular smooth muscle cells -Modulation by the ANP-BNP-CNP system-" Metabolism. (発表予定).

    • Related Report
      1996 Annual Research Report
  • [Publications] 河野雅和: "エンドセリンと高血圧 -特集/エンドセリン研究の新展開" 呼吸と循環, 7 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 横川晃治: "エンドセリンと高血圧 -特集/エンドセリン研究の新展開" 血管と内皮, 6 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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