| Project/Area Number |
08670841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
UEMATSU Masaaki National Cardiovascular Center Research Institute Department of Cardiovascular Dynamics, Chief of Laboratory, 循環動態機能部, 室長 (00270728)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATAKE Kunio National Cardiovascular Center, Director of Cardiology, 内科心臓部門, 部長
YAMAGISHI Masakazu National Cardiovascular Center, Senior Physician, 内科心臓部門, 医長
MATSUDA Hisao National Cardiovascular Center Research Institute Department of Cardiovascular D, 循環動態機能部, 室員 (30229489)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | echocardiography / Doppler / myocardium / velocity / cardiac function / diastole / coronary discase / ultrasound / Doppler / velocity / diastole / coronary discase / coronary disease |
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| Research Abstract |
In this project we sought to develop a clinically feasible method for evaluating left ventricular diastolic function by using a recently emerged tissue Doppler imaging technique.First, we established a system to obtain myocardial velocity gradient, which is defined as a slope of the intramyocardial velocity profile across the myocardial wall, by combining an ultrasound diagnostic apparatus with high sampling rates (Toshiba SSA-380A and a computer image analysis system (Apple Macintosh 8100). We applied this method to patients with artrial septal defect, who are known to have normal left ventricular contraction with exaggerated translatinal motion. We could successfully detect the normal contraction in patients with atrial septal defect using the myocarkial velocity gradient measurement system, validating that the myocardial velocity gradient is independent of the translational motion of the heart. Subsequently, we have developed a faster system that enables clinical interventions, such as dobutamine stress. Even in patients with dilated cardiomyopathy who demonstrated pseudonormalized transmitral flow pattern, peak negative diastolic myocardial velocity gradient remained abnormally attenuated. We further investigated the effect of preload independence of the index in clinical settings and found that it is relatively independent of the preload as compared with transmitral flow indices. We also found that by using myocardial velocity gradient a sensitive detectin of ischemic myocardium was possible in dobutamine stress echocardiography. Thus, the noninvasive measurement of myocardial velocity gradient derived from tissue Doppler imaging is promising for making quantitative and more sensitive diagnosis than conventional methods.
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