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Melatonin kinetics in the patients with neurological disease and sleep disorders

Research Project

Project/Area Number 08670846
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionAsahikawa Medical College

Principal Investigator

MIYAMOTO Akie  Asahikawa Medical College, Department of Pediatrics, Assistant Professor, 医学部, 助手 (10250557)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Satoru  Asahikawa Medical College, Department of Pediatrics, Medical staff, 医学部, 医員
OKI Junichi  Asahikawa Medical College, Department of Pediatrics, Associate Professor, 医学部, 助教授 (60152401)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsneurological disease / Sleep disorder / Melatonin / サルファトキシメラトニン / 中枢神経障害児
Research Abstract

We studied the relationship between sleep disorders and the circadian rhythm of melatonin in 8 children with neurological diseases (West syndrome 4, Rett syndrome 3, Lenz dysplasia 1). The pattern of sleep disorders were non-24 hoursleep-awake syndrome 2, delayed sleep phase syndrome 1 and irregularsleep pattern 5. There were low levels and no peak of melatonin circadian rhythm in two patients with non-24-hour sleep-awake syndrome and delayed peak of melatonin rhythm in one patient with delayed sleep phase syndrome. There were normal rhythm and lower levels melatonin in the patients with irregular sleep disorders. These findings suggests that sleep disorders in patients with neurological diseases may relate with an impaired secretion of melatonin (No to Hattatsu 1997 ; 29 : S200) We treated 14 patients with sleep disorders with oral melatonin ; the dosage was 3-6 mg prior bedtime. We have observed positive effects of melatonin treatment in three areas : hypnotic effect, keep sleep periods, and daily activity. Excellent effects were observed in 3 patients, good effects in 4, mild effects in 5, and no effect in 2. There were no obvious side effects (No to Hattatsu 1998 ; 30 : s22 1). Further clinical and laboratory investigation must be performed to determine the optimal dosage and to investigate whether there are adverse effects of taking melatonin over a long period.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Akie Miyamoto: "Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome." Brain & Development. 21. 59-62 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 田中 肇: "障害児の睡眠障害に対する治療とその療育における意義についての検討." 安田生命社会事業団研究助成論文集. 33. 39-46 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 宮本晶恵: "睡眠障害を伴うRett症候群の血中メラトニン日内リズムとメラトニン治療" 脳と発達. 28. S333 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 宮本晶恵: "中枢神経障害児における睡眠覚醒リズム障害とメラトニン日内リズムの異常" 脳と発達. 29. S200 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 宮本晶恵: "中枢神経障害に伴う睡眠障害に対するメラトニン治療" 脳と発達. 30. S221- (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akie Miyamoto: "Classical Rett syndrome in sisters : variability of clinical expression." Brain & Development. 19. 492-494 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akie Miyamoto: "Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome" Brain & Development. 21. 59-62 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akie Miyamoto: "Serum melatonin kinetics and melatonin treatment for sleep disorders in Rett syndrome" No to Hattatsu. 28. S333 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akie Miyamoto: "Abnormal rhythm of melatonin kinetics and sleep disorders in children with neurological disease." No to Hattatsu. 98. S200 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akie Miyamoto: "Abnormal rhythm of melatonin kinetics and sleep disorders in children with neurological disease." No to Hattatsu. 98. S200 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Akie Miyamoto: "Classical Rett syndrome in sisters : variability of clinical expression." Brain & Development. 19. 492-494 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hajime Tanaka: "Improvement of hypertonus after treatment for sleep disturbances in three patients with severe brain damage." Brain & Development. 19. 240-244 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyamoto A: "Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome" Brain & Development. 21. 59-62 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka H: "Effects of Neonatal Hypoxia on the Medulla-Spinal For Descending Neurons" Pediatric Neurology. 19. 204-210 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takahashi S: "De Novo mt DNA nt 8993(T->G)mutaion sresulting in leigh Syndrome." Am J Hum Genet. 62. 717-719 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 片野俊英: "後遺症なく治癒した急性壊死性脳症の7歳女児例" 小児科臨床. 51. 1091-1095 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Oki J: "Cognitive Deterioration Associated With Focal Cortical Dysplasia" Pediatric Neurology. 20. 73-77 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] A Miyamoto: "Serial imaging in MELAS" Neuroradiology. 39. 427-430 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] A Miyamoto: "Classsical Rett syndrome in sisters:variability of clinical expression" Brain & Development. 19. 492-494 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 宮本晶恵: "Lidocaine 持続点滴と mexiletine経口投与が有効であったLennox-Gastaut症候群の1例" てんかんをめぐってXVIII. 18. in press- (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Satoru Takagashi: "Autopsy Findings in Pyruvate Dehydrogenese E1αDeficiency:Case Report" J Child Neurology. 12. 519-524 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Satoru Takahashi: "L1CAM mutation in a Japanese family with X-linked hydrocephalus:a study for geneic counseling" Brain & Develpment. 19. 559-562 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高橋 悟: "点頭てんかんにおける大脳皮質障害の重要性ー脳室周囲白質軟化を呈した1双生児例での検討" 日児誌. 101. 1706-1712 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 宮本晶恵: "睡眠リズム障害を伴うRett症候群の血中メラトニン日内リズムとメラトニン治療" 脳と発達. 28. S333- (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Akie Miyamoto: "Serial Neuroimages in MELAS ; CT,MRJ and IMP-SPECT Findings" Neurorodiology. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮本晶恵: "てんかん治療後に学習障害が改善した複雑部分発作重積の1男児例" てんかんをめぐって. XVII. 77-81 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮本晶恵: "小児の急性脳炎・脳症におけるSPECTの有用性" 北海道脳SPECT研究会. 4. 55-58 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takahashi S: "CTG trinucleotide repeat length and clinical expression in a fumily" Brain & Development. 18. 127-130 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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