The genes of renin-angiotensin axis as a risk factor for progression of chronic glomerulonephritis
| Project/Area Number |
08670920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nihon University |
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Principal Investigator |
SUHARA Yutaka Nihon University, School of Medicine, Associated Professor, 医学部, 講師 (60171295)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Takeshi Nihon University, School of Medicine, Research assistant, 医学部, 助手 (80256875)
WATANABE Shuichiro Nihon University, School of Medicine, Research assistant, 医学部, 助手 (90297820)
TSUDA Masahiko Nihon University, School of Medicine, Research assistant, 医学部, 助手 (20227416)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | hematuria / chronic glomerulonephritis / angiotensin converting enzyme gene / gene polymorphism / アンギオテンシン変換酵素 |
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| Research Abstract |
Aim of the study) The relation of angiotensin converting enzyme gene polymorphism to the modes of onset of several renal glomerular diseases was studied.
Methods) Genomic DNA of leukocytes was purified for PCR from 63 patients with several glomerular diseases by usual method. PCR was performed to detect insetion (I allele) or deletion (D allele) of Alu sequence in intron 16 of angiotensin converting enzyme gene. These results compared with the modes of onset in each patients.
Results) In patients with IgA nephropathy, the number of DD polymorphism was dominant (II9, ID 4, DD 5, respectively), on the other hand, in patients with asymptomatic hematuria, II polymorphism was dominant ( II11, lD 10, DD 1, respectively).In patients with proteinuria at onset of glomerular diseases, DD polymorphism was dominant compared with the patients showed hematuria alone at the onset (proteinuria ; II8, ID 10, DD 6, hematuria alone ; II20, IID 16, DD 2, respectively).
Conclusion) The polymorphism of angiotensin converting enzyme gene may affects the modes of onset as well as the pregression of renal glomerular diseases.
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Report
(4 results)
Research Products
(7 results)
