Cell cycle regulation of hematopoietic cell from patients with myelodysplastic syndrome
| Project/Area Number |
08670925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
YAMAMOTO Masuji Associate professor, Department of Pediatrics, Hyogo College of Medicine, 医学部, 助教授 (40200844)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJINO Yoshiaki Research Associate Department of Pediatrics Hyogo College of Medicine, 医学部, 助手 (60268547)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | cyclin / cell cycle / MDS (myelodysplastic syndrome) / GM-CSF / TGF-β |
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| Research Abstract |
We determined the expression patterns of D-type cyclins and cyclin-dependent kinases (cdks) in SKM-1 myelodysplastic syndrome (MDS) cells incubated with granulocyte-macrophage colony-stimulating factor (GM-CSF) and/or transforming growth factor-beta1 (TGF-beta1). Our results indicated that TGF-beta1-mediated G1 arrest correlated with the downregulation of cdk4, cdk6 and cyclin D2, and that abrogation of TGF-beta1-mediated G1 arrest by GM-CSF correlated with the constitutive overexpression of cyclin D2 and cdk6 but not cdk4. These results suggest the importance of cyclin D2/cdk6 levels in abrogating G1 arrest in cells exposed to TGF-beta1, and raise the possibility that the GM-CSF-mediated upregulatory pathway of signal transduction through cyclin D2/cdk6 differs from the TGF-beta1-cdk4-mediated pathway in SKM-1 cells.
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Report
(3 results)
Research Products
(16 results)
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[Publications] Hiraumi, Y., Yamamoto, M., Ohtsuki, F., Tsujino, Y., Takaka, A., Kamiya, T., Wada, H.: "Bone marrow transplantation for a patient with Fanconi anemia associated with myelodysplastic syndrome" Jpn J Pediatr Hematol. 11. 47-51 (1997)
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「研究成果報告書概要(欧文)」より
Related Report
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[Publications] Yamamoto, M., Nakagawa, M., Ichimura, N., Ohtsuki, F., Ohtsuka, Y., Tsujino, Y., Tanaka, A., Kamiya, T., Wada, H.: "Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant." Am.J.Hematol.52. 212-214 (1996)
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Publications] Yamamoto, M., Hiraumi, Y., Ichimura, N., Ohtsuki, F., Nakagawa, M., Ohtsuka, Y., Tsujino, Y., Tanaka, A., Kamiya, T., Wada, H.: "Refractory pancreatitis associated with graft-versus-host disease in Fanconi anemia." Am.J.Hematol.52. 329-330 (1996)
Description
「研究成果報告書概要(欧文)」より
Related Report
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