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Transmembrane signaling system concerning super oxide production

Research Project

Project/Area Number 08670937
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

KOIZUMI Hiroko  Medical Hospital, Hokkaido Univ.Lec., 医学部・附属病院, 講師 (60113552)

Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordskeratinocyte / superoxide / calcium / protein kinase C / H202 / C-キナーゼ / cis-urocanic acid / ヒスタミン
Research Abstract

UVB irradiation causes suppression of delayed hypersensitivity. Various photoreceptors and mediators of these changes have been proposed, one of which is cis-urocanic acid formed from the trans-urocanic acid in the epidermis naturally occurring on exposure to UV irradiation. The mechanism by which cis-urocanic acid alters the immune system is not fully clarified. Urocanic acid acts through different mechanisms, perhaps via histamine or histamine-like receptors. Histamine stimulation of keratinocytes induces activation of adenylate cyclase to accumulate cyclic AMP and an increase of intracellular Ca2+. Thus we investigated the effects of cis-urocanic acid on these transmembrane signaling systems in keratinocytes. Normal human keratinocytes were cultured in serum free KGM medium. Cyclic AMP was measured by radioimmunoassay. The alterations of intracellular Ca2+ in single living keratinocytes were measured using an inverted fluorescence microscope and an ARGUS-200/CA digital imaging system. Cis-urocanic acid itself did not induce adenylate cyclase activation in cultured normal human keratinocytes. Cis-urocanic acid inhibited cyclic AMP accumulation by histamine. Keratinocyte growth was not affected by cis-urocanic acid. Cis-urocanic acid did not induce an increase of intracellular Ca2+. Cis-urocanic acid attenuated the histamine induced increase in intracellular Ca2+ but not that induced by epinephrine. The effects of cis-urocanic acid on keratinocytes are revealed through modulation of effects of histamine.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (94 results)

All Other

All Publications (94 results)

  • [Publications] Koizumi H: "Regulation of transmembrane signalling system during senescence of human epidermal keratinocytes" Archives of Dermatological Research. 288. 611-614 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Differentiation assoclated localization of small proline rich protein normal anddiseased skin" British Journal of Dermatology. 134. 686-692 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kartasova T: "Sequence and expression patterns of mouse SPR1 : correlation of expression with epithelial function" Journal of Investigative Dermatology. 106. 294-30 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Herpesvlirus-like sequences in Kaposi′s sarcoma and angiosarcoma in Japan" British Journal of Dermatology. 135. 1009-1010 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T: "Immunoreactive analogues of erythrocyte ankyrin in human epidermal keratinocyte" Archives of Dermatological Research. 288. 19-23 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato Matsumura KC.: "Localization of annexin I (lipocortin I, P35) mRNA in normal and diseased human skin by in situ hybridization" Archives of Dermatological Research. 288. 565-569 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "1,25-Dihydroxyvitamine D3 and a new analogue, 22-oxacalcitrlol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes" Journal of Dermatological Science. 15. 207-213 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "β-Adrenergic stimulation induces activation of protein kinase C and inositol 1,4,5-tripshophate increase in epidermis" Experimental Dermatology. 6. 128-132 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Response to the letter by B. Yalcin et al. (normal serum adenosine deaminase activity in mycosis fungoides)" Acta Dermato-Venereologica. 77. 404 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hagari Y: "Nodular localized cutaneous amyloidosis : further demonstration of monoclonality infiltrating plasma cells in four additional Japanese patients" Brit Dermatol. 138. 652-654 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Cis-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase of intracellular Ca^<2+>" Archives of Dermatological Research. 290. 264-269 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T: "Cis-urocanic acid down-regulates histamine mediated activation of adenylate cyclase in pig epidermis" Acta Derm Venereol (Stockh). 78. 348-350 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Glucocorticold decreases stem cell factor produciton in keratinocytes." J Invest Dermatol. 110. 628 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Congenital onychodysplasia of the index finger with anomalt of the great toe." Acta Derm Venereol. 78. 478-479 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "CD34 positive dendritic cells are intrinsic part of smooth muscle hamartoma." Br J Dermatol. in print.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "H2 histamine receptor-mediated increase in intracellular Ca^<2+> in cultured human keratinocytes." J Dermatol Scl. in print.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉洋子: "増殖とadenosine deaminase皮膚疾患と酵素up to date." Monthly Book Derma. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "IL-18 and IL-18 receptor expression in human keratinocytes." J Invest Dematology. in print.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉 洋子: "単純疱疹. 「今日の治療指針」" 医学書院, 1490 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉 洋子: "Incontinentia pigmenti.カポジ肉腫をめぐる話題. 「皮膚病理をよむ」" 文光堂, 317 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉 洋子: "ダリエ病. 「皮膚疾患最新の治療′97-′98」" 南江堂, 266 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉 洋子: "かゆみQ&A" (株)医療ジャーナル社, 131 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉 洋子: "Key Word 1999-2000 皮膚疾患" 先端医学社 印刷中,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 小泉 洋子: "皮膚科専門医テキスト" 南江堂 印刷中,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Regulation of transmembrane signaling system during senescence of human epidermal keratinocytes" Arch Dermatol Res. 288. 611-614 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Differentiation associated licalization of small proline rich protein in normal and diseased skin" Br J Dermatol. 134. 686-692 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kartasova T.: "Sequence and expression of mouse SPR1" J Invest Dermatol. 106. 294-304 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Herpes virus-like sequences in classic Kaposi's sarcoma and angiosarcoma in Japan" Br J Dermatol. 135. 1009-1010 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T.: "Immunoreactive analogues of erythrocyte ankyrin in human epidermal keratinocytes" Arch Dermatol Res. 288. 19-23 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato-Matsumura KC.: "Localization of annexine I (lipocortin I,P35) mRNA in normal and diseased human skin by in situ hybridization" Arch Dermatol Res. 288. 565-569 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "1,25-Dihydroxy vitamine D_3 and a new analogue, 22-oxa calcitriol, modulate proliferetion and interleukin-8 secretion of normal human keratinocytes" J Dermatol Sci. 15. 207-213 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "beta-adreneragic stimulation induces activation of protein kinase C and inositol 1,4,5-trisphosphate increase in epidermis" Exp Dermatol. 6. 128-132 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Response to the letter by B.Yalcin et al (Normal serum adenosine deaminase activity in mycosis fungoides)" Acta Dermatol Venereol. 77. 404 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hagari Y.: "Nodular localized cutaneous amyloidosis : furtheer demonstration of monoclonality of infiltrating plasma cells in four additional Japanese patients" Br J Dermatol. 138. 652-654 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Cis-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase of intracellular Ca^<2+>" Arch Dermatol Res. 290. 264-269 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shimizu T.: "Cis-urocanic acid down-regulates histamine-mediated activation of adenylate cyclase in pig epidermis" Acta Derm Venereol. 78. 348-350 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Glucocorticoid decreases stem cell factor production in keratinocytes" J Invest Dermatol. 110. 628 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Congenital onychodysplasia of the index finger with anomaly of the great toe" Acta Derm Venereol. 78. 478-479 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "CD34 positive dendritic cells are intrinsic part of smooth muscle hmartoma" Br J Dermatol. (in print).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "H2 histamine receptor-mediated increase in intracellular Ca^<2+> in cultured human keratinocytes" J Dermatol Sci. (in print).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "Adenosine deaminase in cell proliferation" Monthly Book Derma. (in print).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: "IL-18 and IL-18 receptor expression in human keratinocytes" J Invest Dematology. (in print).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: Today's therapy. Igakushoinn, 1490 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: Histopathology of the skin. Bunkodo, 317 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: Current therapy of skin diseases. Nankodo, 266 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: Pruritus Q and A. Iryo-journal, 131 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: Key words in dermatology, 1999-2000. Sentanigakusha (in print),

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H.: Textbook of Dermatology. Mankodo (in print),

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Koizumi H: "Cis-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase of intracellular Ca^<2+>" Arch Dermatol Res. 290. 264-269 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimizu T: "Cis-urocanic acid down-regulates histamine-mediated activation of adenylate cyclase in pig epdermis." Acta Derm Venereol(Stockh). 78. 348-350 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koizumi H: "Glucocorticoid decreases stem cell factor production in keratinocytes." J Invest Dermatol. 110. 628 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hagari Y: "Nodular localized cutaneous amyloidosis : further demonstration of monoclonality of infiltrating plasma cells in four additional Japanese patients." Br J Dermatol. 158. 652-654 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koizumi H: "CD34 positive dendritic cells are intrinsic part of smooth muscle hamartoma." Br J Dermatol. (in print).

    • Related Report
      1998 Annual Research Report
  • [Publications] Koizumi H: "H2 histamine receptor-mediated increase in intracellular Ca^<2+> in cultured human keratinocytes." J Dermatol Sci. (in print).

    • Related Report
      1998 Annual Research Report
  • [Publications] Koizumi H: "Adnexal polyp of neonatal skin observed beyond the neonatal period." Acta Derm Venereol(Stockh). 78. 391-392 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koizumi H: "Congenital onychodysplasia of the index finger with anomalt of the great toe." Acta Derm Venereol. 78. 478-479 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Namba Y: "Specific cutaneous lesions of the scalp in myelodysplastic syndrome with deletion of 20q." J Dermatol. (in print).

    • Related Report
      1998 Annual Research Report
  • [Publications] Sato-Natsumura KC: "Analysis of c-kit exon 11 and exon 17 of urticaria pigmentosa that occured in monozygotic twin sisters." Br J Dermatol. (in print).

    • Related Report
      1998 Annual Research Report
  • [Publications] 小泉洋子: "増殖とadenosine deaminase.皮膚疾患と酵素up to date." Monthly Book Derma. (印刷中).

    • Related Report
      1998 Annual Research Report
  • [Publications] Koizumi H: "IL-18 and IL-18 rceptor expression in human keratinocytes." J Invest Dematology. (in print).

    • Related Report
      1998 Annual Research Report
  • [Publications] 小泉洋子: "皮膚病理をよむ" 文光堂, (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小泉洋子: "皮膚疾患最新の治療'1999-2000" 南江堂, (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 小泉洋子: "Key Word 1999-2000 皮膚疾患" 先端医学社 (印刷中),

    • Related Report
      1998 Annual Research Report
  • [Publications] 小泉洋子: "皮膚科専門医テキスト" 南江堂 (印刷中),

    • Related Report
      1998 Annual Research Report
  • [Publications] Koizumi H: "1,25-Dihydroxyvitamine D3 and a new analogue,22-oxacalcitriol,modulate proliferation and interleukin-8 secretion of normal human keratnocytes" Journal of Dermatiological Science. 15. 207-213 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koizumi H: "β-Adrenergic stimulation induces activation of protein kinase C and inositol 1,4,5-trisphophate increase in epidermis" Experimental Dermatology. 6. 128-132 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koizumi H: "Response to the letter by B.Yalcin et al.(normal serum adenosine deaminase activity in mycosis fungoides)" Acta Dermato-Venereologica. 77. 404-404 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hagari Y: "Nodular localized cutaneous amyloidosis : further demonstration of monoclonality infiltrating plasma cells in four additional Japanese patients" Brit J Dermatol. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] Koizumi H: "Cis-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase of intracellular Ca^<2+>" Archives of Dermatological Research. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] Koizumi H: "Adnexal polyp of neonatal skin seen in two-month and one-year old infant" Acta Demato-Venereologica. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉 洋子: "尋常性乾癬の治療 レチノド療法." Monthly Book Derma. 2. 69-73 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉 洋子: "カボジ肉腫,血管肉腫におけるヘルペスウイルス様DNA塩基配列" Congress Insights in Herpes. 1. 7-9 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abe R: "Dyskeratosis congenita with esophageal stenosis" Proceedings of the 10th Japan Korea Joint Meetings of Dermatology. 306-308 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉 洋子: "膿疱性乾癬および掌蹠膿疱症におけるHLA-遺伝子型" 稀少難性皮膚疾患研究班1997年度報告書. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉 洋子: "ダリエ病.「皮膚疾患最新の治療'97-'98」" 南江堂, 266 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉 洋子: "かゆみQ&A" (株)医療ジャーナル社, 131 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉 洋子: "単純疱疹.「今日の治療指針」" 医学書院, 1490 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小泉 洋子: "Incontinentia pigmenti.カポジ肉腫をめぐる話題.「皮膚病理をよむ」" 文光堂(印刷中),

    • Related Report
      1997 Annual Research Report
  • [Publications] Koizumi H: "Regulation of transmembrane signalling system during senescence of human epidermal keratinocytes" Archves of Dermatological Research. 288. 611-614 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koizumi H: "Differentiation associated localization of small proline-rich protein in normal anddiseased skin" British Journal of Dermatology. 134. 686-692 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kartasova T: "Sequence and expression patterns of mouse SPR1 : correlation of expression with epithelial function" Journal of Investigative Dermatology. 106. 294-304 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koizumi H: "Herpesvirus-like sequences in classic Kaposi′s sarcoma and angiosarcoma in Japan" British Journal of Dermatology. 135. 1009-1010 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu T: "Immunoreactive analogues of erythrocyte ankyrin in human epidermal keratinocyte" Archives of Dermatological Research. 288. 19-23 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato-Matsumura KC.: "Localization of annexin I (lipocortin I, P35) mRNA in normal and diseased human skin by in situ hybridization" Archives of Dermatological Research. 288. 565-569 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu T: "Nonerythroid membrane skeletal protein in normal and diseased human skin" Histology and Histopathology. (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koizumi H: "1, 25-Dihydroxyvitamine D3 and a new analogue, 22-oxacalcitriol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes" Journal of Dermatological Science. (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koizumi H: "β-Adrenergic stimulation induces activation of protein kinase C and inositol 1, 4, 5-trisphophate increase in epidermis" Experimental Dermatology. (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Koizumi H: "Reply to normal serum adenosine deaminase activity in mycosis fungoised by Yalkin et al" Acta Dermato-Venereologica. (印刷中). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu T: "Calcium dependent formation of 4.1-like proteins in cultired human keratinocytes" Biology Cell. 86. 19-26 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 大河原章: "眼球病変を伴いparaneoplastic pemphigusが疑われた症例の免疫ブロット法による検討" 希少難治性疾患研究班1995年度報告書. 14-15 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小泉洋子: "尋常性乾癬の診断と治療" 全日本病院出版会(印刷中),

    • Related Report
      1996 Annual Research Report
  • [Publications] 小泉洋子: "ニューロペプチド.キーワードを読む皮膚科" 医学書院, 166 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小泉洋子: "かゆみQ & A" (株)医療ジャーナル社(印刷中), (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小泉洋子: "ダリエ病.「皮膚疾患最新の治療′97-′98」" 南江堂(印刷中), (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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