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The Consteuction of the animal model for CTCL by SCID mouse

Research Project

Project/Area Number 08670963
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

TACHIBANA Takao (1997)  Kyoto University, Post graduate School of Medicine, Instructor., 医学研究科, 助手 (40179718)

今村 貞夫 (1996)  京都大学, 医学研究科, 教授 (30026869)

Co-Investigator(Kenkyū-buntansha) TANAKA Toshihiro  Kyoto University, Post graduate School of Medicine, Lecture, 医学研究科, 講師 (50188314)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsMycosis Fungoides / CTCL / SCID mouse / Adult T cell leulcrmia / animal model / epidermotropism / Pautrie's abscess / colony formation / 成人T細胞白血病 / 生体内増殖
Research Abstract

Mycosis fungoides is a cutaneous T cell lymphoma with clinical characteristics of epidermal manifistation. It starts as an erythematous stage which shoes poor malignancy and progress to the tumor stage and finaly kills the host. There was no experimental animal model of this disease, thus it was difficult to constract an experimental procedure for the analysis of pathomechanism of this disease for the experimental treatment model in the animals. Our purpose was the establishment of an animal model by modify of ATL model in the SCID mouse. The malignant T cell from the Mycosis Fungoides patient skin was injected intravenous in the SCID mouse. The transplanted malignant T cell survive in the SCID mouse. Colony formations were observed in the lymphnodes, liner, spleen and skin. The skin lesion was not constracted with simple mass formation in the dermis, but it showed the epidermotropism. Pautrie's microabcess which is a histopathological character of Mycosis Fungoides was also abserved in thei animal model. From these data, we concluded that this animal model mimic the Mycosis Fungoides.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Imura Akihiro: "The Human OX40/gp34 System Directly Mediates Adhesion of Activated T cells to Vascular Erdothelial Cells" J.Exp.Med.183. 2185-2195 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Imura Akihiro: "OX40 Expressed on Fresh Leukemic Cells From Adult T cell Leukemia Patient Mediates Adhesion to Vascular Endothelial cells" Blood.89. 2951-2958 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akihiro Imura et al.: "The human OX40 lgp34 system Directly Mediates Adhesion of Activated T cells to Vascular Endothelial cells." J.Enp.Med.183. 2185-2195 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akihiro Imura et al.: "OX40 Expressed on Fresh Lenlcemic cells From adalt T-cell Lenkemia patients mediates cell Adhesim to Vascalar Endo Thelial cells." Blood. 89. 2951-2958 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akihiro Imura: "OX40 Expressed on Fresh Leukemic Cells From Adult T cell-Leukeinic Patient Mediates Cell Adhesion to Vascular Endothelial cells" Blood. 89. 2951-2958 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 今村貞夫: "新しい疾患、診断そして治療" 京都皮膚科医会会報. 21. 16-17 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松吉徳久: "癌転移と接着分子" 臨床皮膚科. 50. 49-53 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 川端栄美: "多彩な皮疹を呈し、ヨード造影剤で増悪しさらに半年後高悪性度リンパ腫に転化したAILD-like T-cell Lymphomaの一例" 皮膚のリンフォーマ. XV. 100-104 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 金澤伸雄: "20年の経過の末、肝臓への瀰慢性浸潤から急速に肝不全が進行し死亡に至った菌状息肉症の1例" Skin Cancer. 11. 172-178 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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