| Project/Area Number |
08670975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | KUMAMOTO UNIVERSITY |
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Principal Investigator |
EGAWA Kiyofumi KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE,ASSISTANT PROFESSOR., 医学部, 講師 (50183215)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Tomomichi KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE,PROFESSOR., 医学部, 教授 (10040586)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | human papillomavirus / type-specific cytopathic effect / intracytoplasmic inclusion body / inclusion wart / epidermoid cyst / eccrine duct / CEA / E4 / ヒトパピローマウイルス / 封入体疣贅 |
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| Research Abstract |
1.In our previous studies, it was revealed that a family of HPVs, HPV4,60 and 65, is associated with not only a specific histologic feature of the homnogeneous intracytoplasmic inclusion bodies but also a characteristic clinical picture of the pigmented warts. In this study we have clearly demonstrated that melanin granules were increased specifically in HPV4/60/65-associated warts, suggesting HPV type-specific pigmentary disorder (Br J Dermatol, 1998). We will attempt immunohistochemical and molecular biological studies to understand the pathomechanism of the HPV type-specific pigmentary disorder in our next year's project.
2.HPV 60 is the only virus that has been found in plantar epidermoid cysts. In the present study we have found HPV 57 in a plantar epidermoid cyst which showed a different histological feature from that of HPV 60-associated plantar epidermoid cyst (Br J Dermatol, 1998). We are investigating the relationshop between the epidermoid cysts and HPV 57 in much larger number of plantar epidermoid cysts.
Using computor we performed three-dimensional reconstruction analysis for the structure of HPV-associated plantar epidermoid cysts, revealing the fine structure of an epidermoid cyst of eccrine duct origin.
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