| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
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| Research Abstract |
Following irradiation of the whole liver of the rat with single fraction of 10 Gy to 25 Gy, dose dependent volume loss of the irradiated liver was observed which did not develop until 30 days after the irradiation. This volume loss was thought to result from endothelial cell damage, leading to infiltration of inflammatory cells, and synthesis of collagen. The necessity of developing an experimental method for analysing the integrated damage of both parenchymal and non-parenchymal cells in the liver after the irradiation.
Clinical assessment of radiation induced hepatic injury using technique of unclear medicine CAT scans. 99mTc-GSA,wich is analog ligand to asialoglycoprotein receptor located on a hepatic cell surface, was employed for analysis of regional liver function. Radiation tolerance of the liver has previously been reported to be around 30 Gy with 2 Gy per fraction. In our clinical case, the uptake of 99mTc-GSA decreased in the area irradiated to 24 Gy with 3 Gy per fraction immediately after completion of the irradiation, which appeared to recover from radiation damage 3 months later. On the CAT scan image 6 months later, there was no findings suggesting of liver fibrosis or atrophy in the area irradiated. The liver damage was obvious and persistant in the area where more than 30 Gy was delivered, and volume loss of the irradiated area developed with time. The regional hepatic functional index rKu were measured before and at 3 weeks after completion of the proton therapy. The rKuvalue tended to decline dose-dependently. The results confirmed that Tc-99m GSA dynamic SPECT is useful for assessing the regional hepatic function, and suggest that this method is sensitive to detect radiation induced hepatic dysfunction.
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