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Multi-energy autoradiography with solid state detector.

Research Project

Project/Area Number 08671004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKEDA Tohoru  University of Tsukuba, Institute of Clinical Medicine, Lecturer, 臨床医学系, 講師 (10197311)

Co-Investigator(Kenkyū-buntansha) AKATSUKA Takao  Yamagata University, Faculty of Engineer, Professor, 工学部, 教授 (80091875)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsAutoradiogram / solid state detector / multi energy spectrum / imaging / biologcal object / Autoradiography / Quantitative analysis / Germanium detector / SSD / Radionuclide
Research Abstract

Now various types of new radionuclide agents, which can reveal the patho-physiological informations of organ, has been developing. For example in the analysis of myocardial tissue, we can assess the various myocardial function ; regional myocardial perfusion using Tl-201 or Tc-99m TF,fatty metabolism using I-123 BMIPP,sympathetic nerve function using I-123 MIBG,and myocardial infarction using Tc-99m PYP.
To understand the patho-physiological conditions in various myocardial diseases as ischemia, cardiomyopathy and heart failure, regional myocardial function mentioned above must be assessed. However, imaging of each agents must be performed separately because the present available detector such as x-ray film or imaging plate cannot separate energy spectrum.
Highly purified germanium solid state (HPGe) detector can detect the energy spectrum of x-ray and gamma ray clearly with highly sensitivity. Multi-energy autoradiographic system was develope in this experiment. This system consisted of (HPGe) detector, collimator, scan table and computer system. Inthe phantom experiment, Tc-99m, I-123 and Tl-201 could clearly imaged. In the normal myocardium perfused by I-125 BMIPP and Tl-201, each agents could be separated clearly. The spatial resolution of this preliminary system was poor comparing to the imaging plate, but the different radionuclide agent colud be clearly separated simultaneously.
Multi-energy autoradiography with solid state detector was thought to have great possibility to analyze patho-physiological condition at same time.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 武田 徹: "半導体検出器を用いたオートラジオグラフィ装置作製の試み" Innervision. 12. 44 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 星野 充紀: "多核種同時計測オートラジオグラフィ" Medical Imaging Technology. 15. 455-456 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tetsuya Yuasa: "Reconstruction method for fluorescent x-ray computed tomography by least-squares method using singular value decomposition." IEEE Transactions on Nuclear Science. 44. 54-62 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 武田 徹: "半導体検出器を用いたオートラジオグラフィ装置作製の試み" 12. 44 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 星野充紀: "多核種同時計測オートラジオグラフィ" Medical Imaging Technology. 15. 455-456 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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