| Project/Area Number |
08671006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | GUNMA UNIVERSITY |
|---|
Principal Investigator |
INOUE Tomio GUNMA UNIVERSITY SCHOOL OF MEDIClNE ASSOCIATE PROFESSOR, 医学部, 助教授 (80134295)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMIYOSHI Katsumi UNIVERSITY SCHOOL OF MEDIClNE FELLOW, 医学部, 助手 (60188802)
ENDO Keigo GUNMA UNIVERSITY SCHOOL OF MEDICINE PROFESSOR, 医学部, 教授 (10115800)
|
|---|
| Project Period (FY) |
1996 – 1997
|
| Project Status |
Completed (Fiscal Year 1997)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
|---|
| Keywords | RADIONUCLIDES / TDM / MULTIDRUG CHEMOTHERAPY / ANTI-CANCER DRUG / CANCER TREATMENT / RI標識治療薬 / ^<123>I-Tamoxifen / 1-123EU / _<111>In-Taxol |
|---|
| Research Abstract |
The aim of this research was as follows :
1) Development of ^<111>In labeled Adriamycin as a new agent
2) Research of ^<111>In labeled Taxol using tumor bearing mice
3) Experiment of ^<123>I-EU using tumor bearing mice
4) Research of radiosynthesis of ^<111>In-Tamoxifen and experimental evaluation of its biodistribution
5) Research of radiosynthesis of ^<18>F-5FU and experimental evaluation of its biodistribution
Radiosynthesis of five different radiolabelled anticancer drugs as described above was succeeded and the biodistribution of ^<111>In labeled Taxol, ^<123>I-EU,and^<18>F-5FU were assessed using tumor bearing mice. The relationships between the concentration of radiolaballed anticancer drugs and the effectiveness on tumor-response of corresponding ant-cancer drugs were not clear. However results of biodistribution obtained in this study encouraged us to use the radiolabelled anti-cancer drugs clinically.
|
