| Project/Area Number |
08671017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
ISODA Haruo Hamamatsu University School of Medicine, Department of Radiology, Clinical Instructor, 医学部附属病院, 助手 (40223060)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEHARA Yasuo Hamamatsu University School of Medicine, Department of Radiology, Assistant Prof, 医学部附属病院, 講師 (70188217)
TAKAHASHI Motoichiro Hamamatsu University School of Medicine, Department of Radiology, Associate Prof, 医学部附属病院, 助教授 (20115489)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | intracranial aneurysm / MR angiography / MR tagging / contrast medium / phantom study / pulsatile flow / intractaniol aneurysm |
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| Research Abstract |
We investigated the flow in lateral saccular and terminal saccular intracranial aneurysm models with different sizes of necks, using tagged MR imaging. We studied 2 lateral and 2 terminal saccular aneurysm models with pulsatile flow. Their height and fundus diameter were 10 mm and their neck diameters were 2.5 mm, 10 mm respectively. Imaging was performed using a 1.5 T superconducting MR system. Tag stripes in the lateral saccular aneurysm models rotated like waterwheels rotate in a stream. A tag stripe in the lateral saccular aneurysm model with a neck size of 10 mm rotated faster than in the aneurysm model with a neck size of 2.5 mm. Although a tag stripe in the terminal saccular aneurysm model with a neck size of 2.5 mm rotated slowly, no distinct tag stripe in the model with a neck size of 10 mm was recognized probably due to very fast flow in the aneurysm model.
We also investigated the signal intensity in these aneurysm models using three dimensional (3D) time-of-flight (TOF) MR angiography with various imaging parameters. Non-contrast 3D TOF MR angiography proved able to delineate terminal saccular aneurysms and/or aneurysms with wider necks, and unable to delineate lateral saccular aneurysms and/or aneurysms with narrower necks. Longer TR or contrast-enhanced MR angiography is recommended in order to allow the spins flowing into the aneurysms to recover.
We compared enhanced 3D MR angiography using ultra fast SPGR with 2D and 3D TOF MR angiography for visualization of the intracranial lateral saccular aneurysm model. Contrast enhanced multiphase 3D MR angiography using ultra fast SPGR with shorter TR and TE more clearly demonstrated the lateral saccular aneurysm model than the other MR angiographic techniques. Contrast enhanced 3D MR angiography was thought to be promising MR angiographic technique for visualizing the intracranial aneurysm.
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