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Study on the mechanism of antitumor adion of platinumcompounds by the utilization of 19.5mpf as the tracer

Research Project

Project/Area Number 08671028
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

AKABOSHI Mitsuhina  KYOTO UNIVERSITY Researd Reaila lnstitute Protessor, 原子炉実験所, 教授 (00027418)

Co-Investigator(Kenkyū-buntansha) TANAKA Yoshiko  KYOTO UNIVERSITY Researd Reaila lnstitute Research Fellow, 原子炉実験所, 助手 (70027449)
MASUNAGA Shinichiro  KYOTO UNIVERSITY Researd Reaila lnstitute Associate Professor, 原子炉実験所, 助教授 (80238914)
ONO Koji  KYOTO UNIVERSITY Researd Reaila lnstitute Protessor, 原子炉実験所, 教授 (90122407)
KAWAI Kenichi  KYOTO UNIVERSITY Researd Reaila lnstitute Research Fellow, 原子炉実験所, 助手 (30110761)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords^<195m>Pt / CDDP / CBDCA / 254-S / DWA2114R / TDDP / Cell-iailling efficiency / hypertheimia / シスプラチン / DWA-2114R / カルボプラチン / 標的量 / ヒラ細胞
Research Abstract

The purpose of this report is to give a short review of the project study on the "mechanism of antitumor action of platinum compounds by the utilization of ^<195m> Pt as the tracer". We have successfully synthesized various 195mPt-radiolabeled compounds and developed the technique to analyze the cell-killing efficiency of Pt atoms from both the mean lethal concentration (D_0) and the number of Pt atoms combined with the biologically important molecules of the treated cells (target volume analysis). This technique was applied to examine the combination effect of these Pt-compounds and hyperthermia. The results revealed that hyperthermia potentially interacted not only with bifunctional (CDDP,CBDCA,254-S,DWA2114R,etc), but also with monofunctional bonds (TDDP,K_2PtCl_4, K_2PtCl_6, etc.) preferably.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] M.Akaboshi: "Relationship betwien cell-Killing efficiency and number of platinum atoms binding to DNA,RNA and protein molecules in HeLa cells" Jpn.J.Cancer Res.87. 178-183 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Ono: "The dose planning of BNCT for brain tumors" Cancer Neutron Capture Therapy. 563-569 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Tanaka: "The effect of ^<60>Co-r-irradiation on K_2PtCl_4 in NH_4Cl solution" Topical,Environ,Chem.53. 191-199 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Cell-killing efficiency and number of platinum atoms binding to DNA,RNA and protein molecules of HeLa cells treated with trans-DDP" Jpn.J.Cancer Res.88. 506-511 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "The relationslip between cellkilling effect and number of lanthanide atoms bound to DNA mollcules in cultured HeLa cells Treated RRE" J.Radianal.Nucl,Chem.217. 179-183 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Enhancement by hyperthermia of cell killing effecf of terra and hexachloroplati against HeLa cell in Vitro." Abstracts 14th Asia Pacific Cancer Conference. 45- (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Relationship between cell-isilling efficiency and number of Platiunm aloms binding to DNA, RNA and protein mole ailes in Hela cells." Jpn.J.Cancer Res.87. 178-183 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Ono: "The dose planning of BNCT for brain tumors." Cancer Neutron Capluve Therapy. 563-569 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Y.Tanaka: "The effect of ^<60>Co-r-inadiation K_2Ptcl_4 in NH_4 Cl solution." Toxicol.Environ, Chem. 53. 191-199 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Cell-isilling effienay and number of platinum atoms binding to DNA, RNA and profein maleeufes of Hela cells treated with combinction of trans diamiue lichloro platinur (11) and bjoerthermia." Jpn.J.Cancer Res.88. 506-511 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "The relationship between cell-lsilling effect and number of lanthanide atoms bound to DNA mclecules in cultured HeLa cells treated with rave earth elements" J,Radioanal.Nucl.Chem. 217. 179-183 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Euhancement by hypertheimic of cell-killing effect of tetra- and heca-chloroplatinums against HeLa cells in uitro" Abst.14th Asia Paaific Cancer Corperence. 45 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] M.Akaboshi: "Relationship between cell-killing effeeiy and number of platinum atoms binding to DNA, RNA and protein molecules in HeLa cells" Jpn.J.Cancer Res.87. 178-183 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Ono: "The dose planning of BNCT for brain tumors" Cancer Neutron Capture Therapy. 563-569 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y.Tanaka: "The effect of ^<60>Co-γ-irradiation on K_2Ptcl_4 in NH_4cl solution" Toxicol.Environ.Chem.53. 191-199 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Akaboshi: "Cell-killing efficiency and number of platinum atoms binding to DNA RNA and protein molecules of HeLa cells Tieated with trans DOP" Jpn.J.Cancer Res.88. 506-511 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Akaboshi: "The relationship between cell killing effect and number of lanthanide atoms bound to DNA molecules in cultured HeLa cells tracted RRE" J.Radional Nucl.Chem.217. 179-183 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Akaboshi: "Entrancement by hyperthamia of cell killing effect of teta and hexa-chloroplatinates against Hela cell in vitro" Abstracts 14th Asia Pacific Cancer Conference. 45 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Akaboshi: "The relationship between Cell-filling efficiency and number of lanthanide atoms bound to DNA molecules in HeLa cells treated with rare earth elements" J.Radioanol.Nucl.Chem. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Akaboshi: "Entranced cell-filling action of cisplatin in th presence d tinbium chloride" J.Radioanal.Nacl.Chem. ((in press))

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Akaboshi: "Cell-hilling efficiency and nuniner of platinum atoms binding la DNA,RNA and protein molecules of HeLa cells treated with Combination of TDDP and hyperthermia" Jpn.J.Cancer Res.((in press))

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Akaboshi: "Relatioship between cell hilling efficiency and number of platinum atoms binding to DNA,RNA and protein molecules of HeLa cells treated with cis diamine(glywldt)pt" Jpn.J.Cancer Res.87-2. 178-183 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Masunaga: "An attempt to enhance chemosensitivity of quiescent cell populatinis in solid lumirs by Combined treatment with nicoti namide and carbogen" J.Cancer Res.Clin Oncol.122. 533-540 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Ono: "Radiobioligical evidence suggerling heterogenous microdistribution of boron compounds in tumors" Int.J.Radiat.Oncol.Biol.Phyo.34. 1081-1086 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 赤星光彦: "放射性同位元素を利用して何ができるか「西原英晃編“研究炉の世界"」" 学術出版印刷, 218 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高田実弥,西村和雄,赤星光彦: "植物体内の微量元素「「西原英晃編“研究炉の世界"」" 学術出版印刷, 218 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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