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DEVELOPMENT OF THE EARLY INDICATOR FOR LATE RADIATION DAMAGE OF KIDNEY

Research Project

Project/Area Number 08671039
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKYUSYU UNIVERSITY

Principal Investigator

OTSUKA Makoto  KYUSHU UNI., MEDICAL INSTITUTE OF BIOREGULATION,ASSOC.PROF., 生体防御医学研究所, 助教授 (60203840)

Co-Investigator(Kenkyū-buntansha) HATAKENAKA Masamitsu  KYUSHU UNI., MED.INST.OF BIOREG., RESEARCH ASSOC., 生体防御医学研究所, 助手 (40253413)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsradiation damage / late effect / mouse kidney / cell proliferation / c-myc / C-myc
Research Abstract

We have previously described the increased proliferation and appearance of abnormally large nuclei in renal proximal tubule cells after radiation. A model has been proposed that the large nuclear cells might be dying and the increased proliferation might lead to mitotic death of these cells and cause functional damage. We measured the amount of c-myc transcript taking the ratio of densities of bands for irradiated left kidney to unirradiated right kidney after RT-PCR procedure on 24 hours after 9,12 and 15 Gy irradiation, and found positive in 1 out of 10 after 9 Gy, 6 out of 10 after 12 Gy and 9 out of 10 after 15 Gy. Measuring c-myc expression seems to be a potential very early indicator of late radiation damage of kidney.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 大塚 誠 他: "腎放射線晩発障害の早期予知法の開発" インナービジョン. 12. 26-26 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 大塚 誠 他: "晩発性放射線腎障害の早期指標としてのc-myc遺伝子の発現" 癌の臨床. 44. 233-234 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Makoto Otsuka, et al.: "Development of the indicator for late radiation damage of kidney." Innervision. 12-8. 26 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Makoto Otsuka, et al.: "Expression of c-myc gene as early indicator of late radiation of kidney." Jpn J Cancer Clinics. 44-2. 233-234 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 大塚 誠 他: "腎放射線晩発障害の早期予知法の開発" インナービジョン. 12・8. 26-26 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大塚 誠 他: "晩発性放射線腎障害の早期指標としてのc-myc遺伝子の発現" 癌の臨床. 44・2. 233-234 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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