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EVALUATION OF ACCURACY OF SPECT IN THE DIAGNOSIS OF BRAIN TUMOR

Research Project

Project/Area Number 08671048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionSAITAMA MEDICAL SCHOOL

Principal Investigator

MACHIDA Kikuo  SAITAMA MEDICAL SCHOOL,FACULTY OF MEDICINE,PROFESSOR, 医学部, 教授 (40010235)

Co-Investigator(Kenkyū-buntansha) HOSONO Makoto  SAITAMA MEDICAL SCHOOL,FACULTY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (00281303)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsIMAGE DATA BASE / BRAIN TUMOR / T1-201 SPECT / MRI / ROC curve / reading experiment / variance among doctors / Tl201-SPECT
Research Abstract

Fifteen-four studies of ^<20l>T1 brain tumor SPECT were independently interpreted by 9 nuclear medicine physicians with and without reference magnetic resonance images in 2 separate sessions to define an effect of referring images, and inter-observer variations. The physicians were requested to detect foci of abnormal deposits, and to discriminate whether they were malignant or not according to 5-grade scaling of subjective diagnostic confidence. Receiver-operating characteristics (ROC) analysis was performed. Mean sensitivity for presence of lesions (SFP), and sensitivity and specifcity for malignancy of ^<201>T1 SPECT were 84, and 53 and 55%, which were changed to 94, and 74 and 55% after referring to the MR images. The SFP was significantly improved (p<0.05), but sensitivity and specificity for malignancy, assessed by areas under the ROC curves, were not significantly improved. Inter-observer variation of the SFP was significantly reduced with addition of the referring MR images. Cerebral lobar localization of lesions by SPECT showed great inter-observer variations (true localization ranged from 30 to 68.4%). It is concluded that ^<201>T1 brain tumor SPECT has moderate sensitivity and specificity for malignancy, which is not improved by addition of anatomical reference images, that additional MR images reduce inter-observer variation of confidence on lesion presence, and that SPECT localization of lesions has great inter-observer variations.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 町田 喜久雄 他: "^<201>Tl SPECT・MRIによる脳疾患診断の医師間変動の評価" 核医学. 33・9. 943-952 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hosono M.et al: "Localization of small-cell lumg cancer xenograft with I-125,In-111 and Re-188-somatostation analogs" Jpn J Cancer Res. 87・9. 995-100 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 長田 久人 他: "小児胆道疾患のMR Cholangiography" 日本画像医学会雑誌. 15・2. 103-108 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 町田 喜久雄 他: "MR angiographyによる門脈系機能評価" 日本臨床 現代臨床機能検査増刊号. 第716号. 48-50 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Inoue Y.: "Effect of angiotensin II on arteriovenous shunting assessed by hepatic arterial perfusion scintig raphy" Am J Clin Oncol. 20・3. 237-241 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 渡部 渉 他: "肝硬変合併食道症の低酸素血症の診断にTc-99m-MAAが有用であった1例" 関東地区呼吸器核医学研究会誌. 12・1. 13-17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 町田 喜久雄 他: "SPECTと耳鼻咽喉科臨床" JOHNS(耳鼻咽喉科・頭頸部外科). 14・1. 123-127 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] MACHIDA,K.et a1.: "Diagnostic Accuracy of T1-201 SPECT MRI in Brain Diseases and Inter-reader Variance of Diagnostic Performance." Kakuigaku. 33. 40-49 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] HOSONO,M.et a1.: "Localization of Small-cell Lung Cancer Xenograft with I-125, In-111 and Re-188-Somatosatin Analogs." Jpn J Cancer Res. 87. 995-100 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] OSADA,H.et a1.: "MR Cholangiography in Pediatric Biliary Tract Diseases" Jpn J Medical lmaging. 15. 103-108 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] INOUE,Y.et a1.: "Effect of Angiotensin II on Arteriovenous Shunting Assessed by hepatic Arterial Perfusion Scintigraphy." J Clinical Oncology. 20. 237-241 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] WATANABE,W.et a1.: "Usefulness of Tc-99m MAA in the Diagnosis of Hypoxemia in Patient with Liver Cirrhosis" Kanto J respiratory Nuclear Medicine. 12. 13-17 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] MACHIDA,K.et a1.: "SPECT and Disease of Nose, Ear and Throat." J Nose, Ear, Throat, Head and Neck Surgery. 14. 123-127 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 町田 喜久雄 他: "201Tl SPECT・MRIによる脳疾患診断の医師間変動の評価" 核医学. 33・9. 943-952 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hosono M et al: "Localization of small-cell lung cancer xenograft with I-125,In-111 and Re-188-somatostatin analogs" Jpn J Cancer Res. 87・9. 995-100 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 長田 久人 他: "小児胆道疾患のMRcholangiography" 日本画像医学会雑誌. 15・2. 103-108 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 町田 喜久雄 他: "MRcholangiographyによる門脈系機能評価" 日本臨床 現代臨床機能検査増刊号. 第716号. 48-50 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Inoue Y: "Effect of angiotensin II on arteriovenous shunting assessed by hepatic arterial perfusion scintigraphy" Am J Clin Oncol. 20・3. 237-241 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 渡部 渉 他: "肝硬変合併食道症の低酸素血症の診断にTc-99m-MAAが有用であった1例" 関東地区呼吸器核医学研究会誌. 12・1. 13-17 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 町田 喜久雄 他: "SPECTと耳鼻咽喉科臨床" JOHNS(耳鼻咽喉科・頭頸部外科). 14・1. 123-127 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 町田喜久雄 他: "^<201>Tl SPECT-MRIによる脳疾患診断の医師間変動の評価" 核医学. 33・9. 943-952 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 本田憲業 他: "MRアンギオグラフィによる肺動脈血流動態の解析" 臨床放射線. 41・1. 23-32 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 町田喜久雄: "心臓SPECTとMRIの進歩" 埼玉医科大学雑誌. 23・1. 99-99 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hosono M et al: "Localization of small-cell lungcancer xenografts with I-125,In-111 and Re-188-somafostatin analogs" Jpn J Cancer Res. 87・9. 995-1000 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 竹田省 他: "進行子宮癌に対するCarboplatinを主体としたNeoadjuvant chemotherapyの有効性と組織内プラチナ濃度との関連について" 日本癌治療学会誌. 31・11. 1090-1098 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 長田久人 他: "小児胆道疾患のMR Chlangiography" 日本画像医学雑誌. 15・2. 103-108 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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