| Project/Area Number |
08671081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
OHTA Tatsuro Nagoya University, School of Medicine , Dept.of Psychiatry Professor, 医学部, 教授 (00109323)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTANI Masako Nagoya University, School of Medicine , Dept.of Psychiatry Professor, 医学部, 教授 (20115637)
ISHII Takashi Nagoya University, School of Medicine , Dept.of Psychiatry Research Associate, 医学部, 助手 (40273239)
KAYUKAWA Yuhei Nagoya University, School of Medicine , Dept.of Psychiatry Research Associate, 医学部, 助手 (20214570)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | sleep-wake rhythm disorder / school refusal / differential diagnosis / melatonin / benzodiazepine / psycho-social factor / psychosomatic disease / prognosis |
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| Research Abstract |
Based on studies of patho-genesis, treatment, epidemiology and prognosis in sleep-wake rhythm disorders, we advanced the investigation of school refusals due to sleep-wake rhythm disorders and got the following results.
1. Analysis of sleep-wake rhythm disorders in high school students using the questionnaire for chronotype of life-style (the revised-version from the Monteflore Medical Center, New York), 7,421 out of 174,000 public high school students in Aichi Prefecture were studied on delayd sleep phase syndrome (DSPS).
(1) Compared DSPS group with non-DSPS group, there existed no significant differences in sleep-wake rhythm pattern of their parents except the "sleep-onset disturbance of mother". There also existed neither family factors nor environmental and regional factors differentiated two groups.
(2) Picking up the limited items of the questionnaire which were characterized by DSPS,called "DSP-score", there was significant difference between DSPS group (possible DSPS) and non-DSPS group (22.20 (]SY.+-。[) 4.50 vs 11.43 (]SY.+-。[) 5.04)
(3) SDS (Zung's) score of both groups (DIPS & non-DSPS) showed no significant difference in depressive state.
2. Treatment trials with melatonin and its response
According to some reports that melatonin treatment for school refusals suffering from sleep-wake rhythm disorders had been successfully carried out by some Japanese researchers, we administered melatonin (1 to 3mg/day) to some adult patients with DSPS and non-24-hour sleep-wake syndrome. This preliminary experiment suggested the possibility of resetting in patients with sleep rhythm disorders who showed an acute improvement of their body temperature rhythm and sleep architecture with melatonin administration.
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