An abnormal transcript of the heat shock protein 70 gene in patients with major depression
| Project/Area Number |
08671113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
SAKAMOTO Kaoru (1997) Tokyo Women's Medical College School of Medicine, Assistant Professor, 医学部, 講師 (30205760)
田村 敦子 (1996) 東京女子医科大学, 医学部, 教授 (30075288)
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| Co-Investigator(Kenkyū-buntansha) |
TOMITAKA Shinichiro Tokyo Women's Medical College School of Medicine, Instructor, 医学部, 助手 (00237124)
坂元 薫 東京女子医科大学, 医学部, 講師 (30205760)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | affective disorder / depression / biologival marker / heat shock protein / うつ病 / 熱ショック蛋白質 |
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| Research Abstract |
The heat shock or stress genes are induced by a wide variety of stimuli including heat, oxidative stress, prolonged seizure, and certain toxins. It is suggested that heat shock proteins may play important roles in the process of mental stress. To our knowledge, there are no report which have investigated the heat shock protein expression in affective disorder.
Thus, we investigated the hsp70 mRNA transcripton in human lymphocyte using RTPCR (reverse transcript polymerase chain reaction). Fourtenn of 15 patients with depression showed abnormal transcript of hsp70. In contrast, normal volunteers show no abnormal trascript. These result suggest Heat shock protein 70 may play an imortant role in the mechanism of depression.
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Report
(3 results)
Research Products
(6 results)
