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Detection of Abnormal Information Processing on Schizophrenic Brain using gamma band EEG

Research Project

Project/Area Number 08671120
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Institute of Psychiatry

Principal Investigator

UCHIDA Sunao  Tokyo Institute of Psychiatry, 精神生理研究部門, 主任研究員 (00261181)

Co-Investigator(Kenkyū-buntansha) MATSUURA Masato  Nihon University, 神経精神医学教室, 助教授 (60134673)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsGamma activity / electrocorticogram / electroencephalogram / schizophrenia / information processing / hippocampus / medial temporal lobe / ガンマ波 / 40Hz
Research Abstract

EEG gamma activity has been draw interests of Neuroscientists since it is considered as a frequency that binds informations in various part of cerebral cortex. However, literature on gamma frequency has been limited to animal literatures, and human gamma oscillation has not been established. In this study, we examine human electrocorticogram obtained from epileptic patients for possible neurosurgical operation. We found 30-150 Hz frequency band is significantly enhanced in medial temporal region compared with basal temporal cortex. Raw EEG data also obtained from this region also showed about 90 Hz regular oscillation.
In this region, 10-20 Hz oscillation was also found. In basal temporal cortex and some part of medial temporal lobe, alpha oscillation was also observed. Alpha oscillation was attenuated in by eyes opening. However, 10-20 Hz oscillation was not attenuated by eyes opening. We think this oscillation also plays an important role in information processing.
We will further investigate these frequencies using ECoG and EEG.We will also extend subject population from epileptic and normal to endogenous psychiatric disorders.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] N.Hirai, S.Uchida, K.Maehara, Y.Okubo, H.Shimizu: "Enhanced gamma(30-150Hz)frequency in human medial temporal lobe." Neuroscience. (印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Uchida, Y.Takizawa, N.Hirai, M.Ishiguro.: "Application of Instantaneous Maximum Entropy Method on human sleep electroencephalogram analysis." IEICE Trans.Fundamentals. E80-A. 965-970 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Uchida, T.Maehara, N.Hirai, Y.Okubo H.Shimizu.: "A case of human natural sleep recording with subdural electrodes showed no sigma(12-16Hz)EEG activity on the orbitofrontal cortex.(abstract)" Electroenceph.Clin.Neurophsiol.(印刷中). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 内田 直: "睡眠ポリグラムのコンピュータによる解析" 日本臨床. 56(2). 493-498 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 内田 直: "睡眠脳波のコンピュータ解析-脳波スペクトルの一夜の経時的変化-" 脳波と筋電図. 25(6). 432-436 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sunao Uchida, Nobuhide Hirai: "Brain Topography Today.Y.Koga,K.Nagata,K.Hirata editors" Human sleep EEG oscillations and their neurophysiological significance., 291-296 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 内田 直、小島 卓也: "『最新 脳と神経科学シリーズ』第10巻 「睡眠とその障害」" 睡眠の神経機構-睡眠の脳波機構, 25-34(233) (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Hirai, S.Uchida, K.Maehara, Y.Okubo, H.Shimizu: "Enhanced gamma (30-150 Hz) frequency in human medial temporal lobe." Neuroscience. [in print]. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Uchida, Y.Takizawa, N.Hirai, M.Ishiguro: "Application of Instantaneous Maximum Entropy Method on human sleep electroencephalogram analysis" IEICE Trans.Fundamentals. E80-A. 965-970 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Uchida, T.Maehara, N.Hirai, Y.Okubo, H.Shimizu: "A case of human natural sleep recording with subdural electrodes showed no sigma (12-16 Hz) EEG activity on the orbitofrontal cortex." (abstract). Electroenceph.Clin.Neurophysiol.[in print]. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Uchida: "Computer analysis of polysomnography" Nippon Rinsho. 56 (2). 593-498 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Uchida: "Computer analysis of sleep EEG-across night changes of EEG spectrum" Japanese Journal of EEG and EMG. 25 (6). 432-436 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sunao Uchida, Nobuhide Hirai: Human sleep EEG oscillations and their neurophjysiological significance. Brain Topogrphy Today.Y.Koga, K.Nagata, K.Hirata editors Elsevier Science, Amsterdam, 291-296 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Uchida, T.Kojima: Neural mechanism of sleep-EEG generation during sleep.Brain and Neuroscience Series Vol.10 Sleep and sleep disorders., 25-34 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Hirai,S.Uchida,K.Maehara,Y.Okubo,H.Shimizu: "Enhanced gamma(30-150Hz)frequency in human medial temporal lobe." Neuroscience. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Uchida,Y.Takizawa,N.Hirai,M.Ishiguro.: "Application of Instantaneous Maximum Entropy Method on human sleep electroencephalogram analysis." IEICE Trans.Fundamentals. E80-A. 965-970 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Uchida,T.Maehara,N.Hirai,Y.Okubo H.Shimizu.: "A case of human natural sleep recording with subdural electrodes showed no sigma(12-16Hz)EEG activity on the orbitofrontal cortex.(abstract)" Electroenceph.Clin.Neurophysiol.(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 内田 直: "睡眠ポリグラムのコンピュータによる解析" 日本臨床. 56(2). 493-498 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 内田 直: "睡眠脳波のコンピュータ解析 -脳波スペクトルの一夜の経時的変化-" 脳波と筋電図. 25(6). 432-436 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sunao Uchida,Nobuhide Hirai: "Brain Topography Today.Y.Koga,K.Nagata,K.Hirata editors" Human sleep EEG oscillations and their neurophysiological significance., (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 内田 直、小島卓也: "『最新 脳と神経科学シリーズ』第10巻 「睡眠とその障害」" 睡眠の神経機構-睡眠の脳波機構(印刷中), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] S.Uchida,M.Matsuura et al.: "Computerization of Fujimori′s method of waveform recoguitim. A review and methodological considerationg for …" Journal of Neuroscience Methods. 64. 1-12 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Uchida et al.: "Flunitrazepam effects on hwnan sleep EEG Spectra" Life Sciences. 58. PL199-205 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Uchida et al.: "Flunitrazepam effects on human sleep EEG Spectra II" Lif Sciences. 59. PL117-120 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Takizawa,S.Uchida et al.: "Application of Instantaneons Maximum Entropy Method…" IEICE Transaction of Fundamental′s. (印刷中). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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