| Project/Area Number |
08671133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内分泌・代謝学
|
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| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
OKUDA Yukichi Associate Professor Institute of Clinical Medicine University of Tsukuba, 臨床医学系, 助教授 (60211132)
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| Project Period (FY) |
1996 – 1998
|
| Project Status |
Completed (Fiscal Year 1998)
|
| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Diabetes / VEGF / Diabetic retinopethy / Hypoxia / Cultured endothelial and smooth muscle cells / Sports medicine / 高グルコース / プロゲステロン / GKラット / 培養網膜細胞 / エストラジオール |
|---|
| Research Abstract |
We determined the levels of vascular xxxxxx (grooooowth factor/vascular permeability factor (VFGF/VPF) in the aqueous and serum in non-insulin dependent dixxx patients with proliterative retinopathy and neovascular glancoma, and normal subjects. The levels of VEGF were very high in patients with diabetic patients with retinopathy and subjects with physical training at high altitudes.
Also, hypoxia and endothelin-I constitute potent stimuli for VEGF production in cultured vascular cells.
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