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Graves' & Hashimoto's diseases and apoptosis

Research Project

Project/Area Number 08671175
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内分泌・代謝学
Research InstitutionUniversity of the Ryukyus

Principal Investigator

TAKASU Nobuyuki  University of the Ryukyus, Department of Medicine, Prof, 医学部, 教授 (20020927)

Co-Investigator(Kenkyū-buntansha) ASAWA Takayuki  University of the Ryukyus, Department of Medicine, Instruct, 医学部, 助手 (80281228)
KOMIYA Ichiro  University of the Ryukyus, Department of Medicine, Ass Prof, 医学部, 助教授 (50162061)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsGrave's disease / Hashimoto's disease / thyrotoxicosis / hypothyroidism / TSH receptor antibody / TRAb / TSAb / ATL / 甲状腺自己免疫疾患 / アポトーシス / 成人T細胞白血病 / HTLV-I carrier
Research Abstract

There are two autoimmune thyroid diseases ; Graves' and Hashimoto's diseases. The former causes thyrotoxicosis and the latter hypothyroidism. There are many patients with Graves' and Hashimoto's diseases. However, the mechanisms for the development of both diseases are still poorly known. Apoptosis might play some roles in the development of Graves' and Hashimoto's diseases.
1)Graves' disease TRAb (TSH receptor antibody) causes Graves' disease. This TRAb is thyroid stimulating antibody (TSAb). This TSAb stimulates thyroid glands and increases thyroid hormone synthesis and secretion ; thus TSAb causes thyrotoxicosis. We studied TSAb and TBII (TSH-binding inhibitory IgG) as TRAb in 277 untreated Graves' patients and 686 normal control subjects (Takasu N et al : J Endocrinol Invest 20 : 452-461,1997). ROC analysis revealed that cut-off value for TSAb is 150% and that for TBII is 10%. Almost all untreated Graves' patients have positive TSAb and/or TBII.TSAB and TBII decreased to normal levels with antithyroid drug treatment. The changes of TSAb and TBII predict the clinical courses of Graves' patients.
Hashimoto's diseases Lymphocyte abnormality plays an essential role in the development of Hashimoto's thyroiditis. Adult T-cell leukemia (ATL) is a disease of T-lymphocyts. Immune abnormalities are seen in ATL patients. We reported that high prevalence of Hashimoto's thyroiditis in the patients with ATL and HTLV-I carriers (Clin Endocrinol 45 : 461-466,1996).We also revealed the mechanism of the development of blocking antibody-induced hypothyroidism in the patients with atrophic thryoiditis (Clin Endocrinol 47 : 319-324,1997).

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Takasu N et al.: "Thyroid-gtimulating antibody and TSH-birding inhibitor immunoglobulin in 277 Graves′ patient and in 686 normal sabjects" J Endocrinol Invest. 20. 452-461 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kouki T, Takasu N et al.: "Demonstration of fragments with thyroid stimulqting activity from thyaid stimulation blocking antibodies-IgG molecbles Beg papain digestion" Clin Endocrindogy. 47. 319-324 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akamine H, Takasu N et al.: "High prevalence of GAD 65(and IA-2)antibodies in Japanese IDDM patiento by a new inmuraprecipitotion assay based on recombinant fuman GAD65" Diabet Med. 14. 778-784 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Komiya I, Takasu N et al.: "An abnormal sodium metabolism in Japanese potients with eusential hypertension,judged by sermm sodiun distribution,renal function and" J Hypert. 15. 65-72 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akamine H, Takasu N et al.: "Association HTLV-I with autommune thyroiditis in patiexts with adult T-cell leuemia(ATL)and HTLV.I carriers" Clin Endocrirolgy. 45. 461-466 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohshiro K, Takasu N et al.: "Molecuila cloning of rat maerophage-stimulating protein and ito inrolnmenl in the male reprodutive selatem" Biochem Biophxp Res Commun. 227. 273-280 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takasu N: "Primary culture of thyvoid cells" Dayle A,Grittitho TB & Newell DG Ed,Cell & Tissue Culture John Wiley & Sons,ltd., 56 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 高須 信行: "甲状腺" 市川厚,岡孝巳編「ホルモン、生理活性物質I」広川書店, 42 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takasu et al :"Thyroid-stimulating antibody and TSH-binding inhibitory immunoglobulin in 277 Graves'patients and in 686 normal subjects." J Endocr Inv. 20. 526-532 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kouki, Takasu et al :"Demonstration of fragments with thyrid stimulating activity from thyroid stimulation blocking antibodies molecules by papain digestion." Clin Endocrinol. 47. 319-324 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akamine, Takasu et al :"High prevalence of GADA65 (and IA-2) antibodies in Japanese IDDM patients by a new immunoprecipitation assay based on recombinant human GAD65." Diabet Med. 14. 778-784 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Komiya, Takasu et ai :"An abnormal sodium metabolism in Japanese patients with essential hypertension, judged by sodium distribution, renal function and the renin-aldosterone system." J Hypertension. 15. 65-72 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Akamine, Takasu et al :"Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell Leukemia (ATL) and HTLV-I carriers." Clin Endocrinol. 45. 461-466 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohshiro, Takasu et al :"Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system." Biochem Biophys Res Commun.227. 273-280 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimabukuro, Takasu et al :"Cardioprotective effects of troglitazone in streptozocin-induced diabetic rats." Metabolism. 45. 1168-1173 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimabukuro, Takasu et al :"Increased QT dispersion and cardiac adrenergic dysinnervation in diabetic patients with autonomic neuropathy." Am J Cardiol. 78. 1057-1059 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takamatsu, Takasu et al :"Inhibitory action on thyroid-peroxidase activity by immunoglobulin G from atrophic hypothyroid patients with or without thyroid stimulation-blocking antibody." Thyroidol Clin Exp. 8. 45-49 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shinzato, Takasu et al :"Effect of gliclazide on the functional response to calcium in diabetic rat heart." Gen Pharmc. 27. 471-475 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takasu N et al.: "Thyroid-stimulating antibody and TSH-binding inhibitor immunoglobulin in 277 Graves' patients and in 686 normal subjects" J Endocrinol Invest. 20. 452-461 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kouki T,Takasu N et al.: "Demonstration of fragments with thyroid stimulating activity from thyroid stimulation blocking antibodies-IgG molecules by papain digestion" Clin Endocrinology. 47. 319-324 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akamine H,Takasu N et al.: "High prevalence of GAD65(and IA-2)antibodies in Japanese IDDM patients by a new immunoprecipitotion assay based on reconbinant human GAD65" Diabet Med. 14. 778-784 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Komiya I,Takasu N et al.: "An abnormal sodium metabolism in Japanese patients with essential hypertension,judged by serum sodiun distribution,renal function and" J Hypert. 15. 65-72 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akamine H,Takasu N et al.: "Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell leukemia(ATL)and HTLN-I carriers" Clin Endocrinology. 45. 461-466 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohshiro K,Takasu N et al.: "Molecular cloning of rat macrophage-stimulating protein and its involvement in th male reproductive system" Biochem Biophys Res Commun. 227. 273-280 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takasu N: "Primary culture of thyroid cells" Doyle A,Grittiths JB & Newell DG Ed,Cell & Tissue Culture John Wiley & Sons,Ltd, 56 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 高須信行: "甲状腺" 市川厚、岡孝巳編「ホルモン・生理活性物質I」広川書店, 42 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takasu N: "Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell leukaemia" Clin Endocrinol. 45. 461-466 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takasu N: "Enhancement of postischemic myocardial stunning by calcium overload in hearts of diabetic rats." Life Sci. 58. 1291-1299 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takasu N: "Late complications in traumatic coronary artery fistula : report of a case requiring surgical" Cardiology. 87. 86-89 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takasu N: "Molecular Cloning of Rat Macrophage-Stimulating Protein and Its Involvement in the Male" Biochem Biophys Res Commun. 227. 273-280 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takasu N: "Cardioprotective effects of troglitazone in streptozocin-induced diabetic rats." Metabolism. 45. 1168-1173 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Asawa T: "Glutamic acid decarboxylase autoantibody assay using ^<125>I-labelled recombinant GAD_<65>" Clinica Chimica Acta. 256. 175-188 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takasu N: "Primary culture of thyroid cells." In Doyle A,Griffiths JB,& Newell DG,Ed,Cell & Tissue Culture : Laboratory Procedures., 50 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高須信行: "甲状腺" 市川厚,岡孝巳編集「ホルモン・生理活性物質I」,広川書店,東京, 45 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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