| Project/Area Number |
08671182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内分泌・代謝学
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| Research Institution | TEIKYO UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
KINOSHITA Makoto TEIKYO UNIVERSITY SCHOOL OF MEDICINE ASSOCIATE PROFESSOR, 医学部, 助教授 (70186295)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Hiroyuki DEPARTMENT OF PHARMACOLOGY,TOKYO UNIVERSITY ASSOCIATE PROFESSOR, 薬学部, 助教授 (40167987)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | PAF acetylhydrolase / atherosclerosis / oxidized LDL / 動脈硬化症 / PAFアセチルヒドロラーゼ / リゾリン脂質 / ホルモン補充療法 |
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| Research Abstract |
Platelet activating factor (PAF) acetylhydrolase is known as an inactivator of PAF.Serum PAF acetylhydrolase is carried by lipoproteins, mainly by low density lipoprotein (LDL), and it is known to release lysophosphatidylcholine from oxidized LDL.Therefore, it is possible that PAF acetylhydrolase play roles on lipid metabolism and formation of atherosclerosis.
Using serum of PAF acetylhydrolase deficient patient, it was revealed that PAF acetylhydrolase deficient serum was less susceptible to oxidation by copper. And probucol or interferon made serum PAF acetylhydrolase activity higher than control. These results indicate that PAF acetylhydrolase play some roles on lipid metabolism and is regulated by some drugs. Futher in vitro experiment is necessary to evaluate the direct effects of PAF acetylhydrolase on atherosclerosis.
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