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Application of anti-cell adhesion molecule therapies for renal diseases.

Research Project

Project/Area Number 08671287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionOkayama University

Principal Investigator

MAKINO Hirofumi (1997)  Okayama University Medical School, Professor, 医学部, 教授 (50165685)

四方 賢一 (1996)  岡山大学, 医学部, 助手 (00243452)

Co-Investigator(Kenkyū-buntansha) KUNITOMI Mie  Okayama University Medical School Hospital, Senior Resident, 医学部・附属病院, 医員
TSUCHIYAMA Yoshinori  Okayama University Medical School Hospital, Senior Resident, 医学部・附属病院, 医員
SHIKATA Kenichi  Okayama University Medical School Hospital, Lecturer, 医学部・附属病院, 講師 (00243452)
山地 浩明  岡山大学, 医学部・附属病院, 医員
林 佳子  岡山大学, 医学部・附属病院, 医員
槙野 博史  岡山大学, 医学部, 教授 (50165685)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsKidney / Adhesion molecule / ICAM-1 / Selectin / Glomerulonephritis / Diabetes / Sulfatide / Therapy / 炎症 / 免疫 / マクロファージ / 好中球
Research Abstract

We have investigated the possibility of application of anti-cell adhesion molecule therapies for renal diseases. In summary,
1. We showed the up-regulated expression of ICAM-1, E-selectin and P-selectin in the glomeruli and interstitium of the kidney or the patients with glomerulonephritis and diabetic nephropathy.
2. We calrified the mechanism that glomerular hyperfiltration induces intraglomerular expression of ICAM-1 and infiltration of macrophages.
3. We showed that the ligands for L-selectin exist in the cytoplasm of tubular epithelial cells and re-distribute to the interstitium and peritubular capillaries after ureteral ligation in rat kidney. Furthermore, we showed that one of the ligands for L-selectin is sulfatide.
4. We showed that administration of sulfatide which is a ligand for L- and P-selectin inhibits the infiltration of macrophage to renal interstitium in vivo.
5. We showed that prostaglandin I_2 ameliorates renal injury by inhibition of ICAM-1 expression in rat crescentic glomerulonephritis model.
These results showed the critical role of ICAM-1 and selectins for the infiltration of macrophege into renal tissues in various types of glomerular diseases. In conclusion, our results suggest the beneficial effects of anti-cell adhesion molecule therapy for glomerular diseases.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] 杉本 光: "Increased expression of intercellular adhesion molecule-1(ICAM-1)in diabetic rat glomcruli-Glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation-" Diabetes. 46. 2075-2081 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 四方賢一: "Roles of cell adhesion molecule in progression of renal diseases and anti-cell adhesion molecule therapies for renal diseases." Cell-cell interaction in kidney. 79-82 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 久代 正彦: "Therapentic effects of prostacyclin analog on cresoentic glomerulonephritis of rat." Kidney International. 53. 1314-1320 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 宮武伸行: "Intercellular adhesion molecule 1 mediates mononuclear cell infiltration into rat glomeruli after renal ablation." Nephron. 79. 91-98 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 平田教至: "Increased expression of selectins in kidney of patients with diabetic nephropathy." Diabetologta. 41. 185-192 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 川端研二: "Soluble P-selectin is released from activated platelets in vivo during hemodialysis." Nephron. 78. 148-155 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 四方賢一: "L-selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction" Journal of Pathology. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 四方賢一: "腎疾患と接着分子" BIO Clinica. 12. 967-972 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 槇野博史: "糖尿病性腎症の発症・進展機序" Diabetes Journal. 25. 1-25 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 四方賢一: "インテグリン受容体と接着分子" 腎と透析. 45. 366-378 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 四方賢一: "糸球体障害に引き続く間質障害-接着因子" 腎と透析. 45. 79-87 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 松田光浩: "腎疾患と接着分子" 医学のあゆみ. 187. 77-82 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 和田 淳: "腎疾患と接着分子" 臨床免疫. 30. 269-275 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 四方賢一: "間質・尿細管3.発症進展における接着分子の役割" Annual Review 腎臓. 98-107 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sugimoto H,Shikata K,Hirata K,Akiyama K,Matsuda M,Kushiro M,Shikata Y,Mayatake N,Ota K,Miyasaka M,Makino H: "Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli-Glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation-" Diabetes. 46. 2075-2081 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikata K,Hirata K,Matsuda M,Shikata Y,Wada J,Shimizu F,Makino H: "Roles of cell adhesion molecule in progression of renal diseases and anti-cell adhesion molecule therapies for renal diseases." Nihon Igakukan, Tokyo, Japan.Cell-cell interaction in kidney.79-82 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kushiro M,Shikata K,Sugimoto H,Shikata Y,Miyatake N,Wada J,Miyasaka M., Makino H.: "Therapeutic effects of prostacyclin analog on crescentic glomerulonephritis of rat." Kidney International. 53. 1314-1320 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Miyatake N,Shikata K,Sugimoto H,Kushiro M,Shikata Y,Ogawa S,Hayashi Y,Miyasaka M,Makino H: "Intercellular adhesion molecule 1 mediates mononuclear cell infiltration into rat glomeruli after renal ablation." Nephron. 79. 91-98 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hirata K,Shikata K,Matsuda M,Akiyama K,Sugimoto H,Kushiro M,Makino H: "Increased expression of selectins in kidney of patients with diabetic nephropathy." Diabetologia. 41. 185-192 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawabata K,Nagake Y.Shikata K,Fukuda S,Nakazone H,Takahashi M,Ichikawa H,Makino H: "Soluble P-selectin is released from activated platelets in vivo during hemodialysis." Nephron. 78. 148-155 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikata K,Suzuki Y,Hirata K,Matsuda M,Akiyama K,Sugimoto H,Wada J,Suzuki T,Makino H,Miyasaka M: "L-selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction." Journal of Pathology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikata K,Sugimoto H,Makino H: "Renal disease and adhesion molecule." BIO Clinica. 12. 967-972 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Makino H,Shikata K,Sugimoto H: "Mechanism of development of diabetic nephropathy." Diabetes Journal. 25. 1-25 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikata K,Sugimoto H,Wada J,Makino H: "Integrin receptors and adhesion molecule." Kidney and Dialysis. 45. 366-378 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikata K,Sugimoto H,Wada J,Makino H: "Interstitial injury follwed by glomerular injury-adhesion molecule" Kidney and Dialysis. 45. 79-87 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Matsuda M,Shikata K,Wada J,Makino H: "Renal disease and adhesion molecule." Igaku No Ayumi. 187. 77-82 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Wada J,Shikata K,Makino H: "Renal disease and adhesion molecule." Rinsyoumeneki. 30. 269-275 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shikata K,Makino H: "Role of adhesion molecule in development of glomerular disease." Annual Review Kidney. 1999. 98-107 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 槇野 博史 他: "糖尿病性腎症概論 病理と形態" 糖尿病と透析療法. 53-63 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 弘中 一江 他: "糖尿病性腎症の尿球体病変-免疫組織化学および電顕的検討-" Diabetes Frontier. 7. 521-526 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 槇野 博史 他: "糖尿病性腎症における尿細管異常とAGE" 内分泌・糖尿病科. 3. 512-518 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 槇野 博史 他: "腎障害を伴う糖尿病の治療" Medical Practice. 13. 923-927 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 槇野 博史 他: "腎臓病 最近の話題 サイトカインと接着分子" 富士レビオ株式会社, 248 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawabata K.et al.: "The changes of Mac-1 and L-selectin expression on glanulocytes and soluble L-selectin level during hemodialysis." Nephron. 73. 523-579 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsuda M.et al.: "Glomerular expression of macrophage colony-stimulating factor and granulocyte colony stimulating factor in patients with various forms of glomerulonephritis." Laboratory Investigation. 75. 403-412 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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