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Phenotypically changed mesangial cells glomerulosclerosis associated with hyperlipidemia in primary FSGS.

Research Project

Project/Area Number 08671306
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionTokyo Women's Medical College

Principal Investigator

HATTORI Motoshi  Tokyo Women's Medical College, Medicine, Lecture, 医学部, 助手 (50192274)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Yutaka  Tokyo Women's Medical College, Medicine, Assistant Professor, 医学部, 助教授 (60057073)
YOSHIOKA Yoshimasa  Tokyo Women's Medical College, Medicine, Assistant Professor, 医学部, 助教授 (60146438)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
KeywordsNephrotic Syndrome / Hyperlipidemia / Renal injury / Glomerulosclerosis / Mesangial cell / Phenotypic change / Macrophage / Focal segmental glomerulosclerosis
Research Abstract

Patients with steroid-resistant nephroric syndrome due to primary focal segmental glomerulosclerosis (FSGS) have a grave prognosis. The purpose of this study was to examine the pathological role of phenotypically changed mesangial cells in the process of glomerulosclerosis in primary FSGS.The results of this study indicate that 1) mesangial cells undergo phenotypic changes to myofibroblasts, 2) phenotypically changed mesangial cells to myofibroblast participate in the active scarring by de novo synthesis of interstitial collagens, and 3) growth factors originating from infiltrating macrophages may be responsible for the mesangial phenotypic changes. The interaction between mesangial cells and infiltrating macrophages is now under investigation in view of glomerular expression of macrophage-colony stimulating factor.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Hattori M etal.: "Mesangial pherotypic changes associated with cellular lesions in primary focal segmental glomerulosclerosis" American Journal of Kidney Diseases. 30. 632-638 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Miyazaki K et al.: "UP-regulation of macrophage colony-stimuating factor(M-CSF) and migration inhibitory factor(MIF) expression and monocyte recruitment during lipid:induced glomenilar injury in the exogenous hypercholesterolaemic (EXHC) rat" Clinical and Experimental Immunology. 108. 318-323 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 服部 元史 他: "高脂血症病態下におけるマクロファージの糸球体内浸潤機序とその病的意義" 日本小児腎臓病学会雑誌. 10. 189-194 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori M,et al: "Mesangial phenotypic changes associated with cellular lesions in primary focal segmental glomerulosclerosis" Am J Kidney Dis. 30. 632-638 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Miyazaki K,et al: "Up-regulation of macrophage colony-stimulating factor (MCSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat." Clin Exp lmmunol. 108. 318-323 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori M,et al: "Macrophage recruitment and it's pathological significance in lipid-induced glomerular injury." Jpn J Pediatr Nephrol (Japanese). 10. 189-194 (1977)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hattori M, et al.: "Mesangical phenotypic changes associated with cellular lesions in primary focal segmental glomerulosclerosis" American Journal of Kidney Diseases. 30. 632-638 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Miyazaki K, et al.: "Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during Lipid-induced glomerulor injury in the exegenous hyperchobesterolaemic (EXHC) rat" Clinical and Experimental Immunology. 108. 318-323 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 服部元史, 他: "高脂血症病態下におけるマクロファージの糸球体内浸潤機序とその病的意義" 日本小児腎臓病学会雑誌. 10. 189-194 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Motoshi Hattori: "Mesangial phenotypic changes associated with cellular lesion in primary tocal segmental glomerulosclerosis" Am.J.Kidney.Dis.(in press).

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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