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Research of the Effects of New Ventilatory Therapy Using the Combination of PLV and NO to Neonates

Research Project

Project/Area Number 08671314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTohoku University

Principal Investigator

SAKAI Takeo  Tohoku University hospital, Associate Professor, 医学部・附属病院, 助教授 (90186990)

Co-Investigator(Kenkyū-buntansha) ONO Tadayuki  Tohoku University hospital, 医学部・附属病院, 医員
OZAWA Akira  Tohoku University hospital, 医学部・附属病院, 医員
TANAKA Takasi  Tohoku University hospital, Research Associate, 医学部・附属病院, 助手 (10292335)
AIBA Satoru  Tohoku University hospital, Research Associate, 医学部・附属病院, 助手 (20261612)
柿澤 秀行 (柿沢 秀行)  東北大学, 医学部・附属病院, 助手 (90241611)
高橋 立子  東北大学, 医学部・附属病院, 医員
小沢 晃  東北大学, 医学部・附属病院, 医員
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsPartial liquid vantilation / Respiratory distress syndrome / Nitrric oxide / High-frequency oscillatory / ventilation / Partial liquid ventilation / high frequency ocsillation / Liquid ventilation / Respinatoru distress syndrome / Newborn
Research Abstract

Partial liquid ventilation (PVL) with perfluorocarbon (PFC) improves pulmonary gas exchange in the respiratory distress syndrome (RDS). Nitric oxide (NO) is an endothelium-derived relaxing factor in a gaseous form. When inhaled at low concentrations, it may relax constricted pulmonary vascular smooth muscle. We hypothesized the combination of PVL and NO can be more effective to the patients with RDS than when PVL or NO is used alone. Therefore, we conducted animal experiments to investigate this hypothesis. We made RDS animal model using newborn piglets by lung lavage with warm saline.
First, the optimal volume of PFC was investigated, Functional residual capacity (FRC) of the animals were 26 ml before lavage and 14 ml after lavage. Lung compliance improved as the volume of PFC was increased from 5 ml/kg to 30 ml/kg in 5 ml increments. However, oxygenation and CO2 elimination worsened at the volume of 25 ml/kg and 30 ml/kg of PFC.These results led us to conclude 15-20 ml/kg, that is very close to FRC, maybe optimal dose of PFC to the patients with RDS.
Second, we compared the effects of two different ventilation mode with PLV, which were conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV). During CMV, PLV was able to keep good oxygenation and ventilation. However, once CMV was changed to HFOV, arterial blood gas value worsened. And when animals were changed to CMV again after ventilated by HFOV, blood gas value showed improvement, From these results, we conclude that HFOV is not adequate ventilation mode for PLV.
Third, we conducted the another experiment that investigated the mutual effects of the combination of NO and PLV.Oxygenation of piglets remarkably improved during the combination of PLV and NO compared with PLV only. However, we could not performed sufficient number of experiments, therefore, definitive conclusion was not able to be demonstrated here.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 堺 武男: "部分液体換気" 周産期医学. 28・4. 486-492 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 堺 武男: "Patient triggered ventilation" 小児内科. 30・12. 1525-1529 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takeo Sakai, et al: "Effects of Mean and Swing Pressure during Piston-type HFOV" Pediatric Pulomonology. 27・5. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai T,Kakizawa H,Aiba S et al.: "Effects of mean and swing pressures on piston-type high-frequency oscillatory vantilation in with and without acute lung injury" Pediatr Pulmonol.27 : (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai T.: "Partial liquid vantilation." Perinatal Med.28. 486 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai T.: "Pulmonary interstitial emphysema during piston-type high-frequency oscillatory vantilation." Tohoku J Exp Med.180. 327 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 堺 武男: "部分液体換気" 周産期医学. 28・4. 486-492 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堺 武男: "Patient triggered ventilation" 小児内科. 30・12. 1525-1529 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takeo Sakai, et al: "Effects of Mean and Swing Pressure during Piston-type HFOV" Pediatric Pulomonology. 27・5. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堺 武男: "高頻度人工換気" 小児内科. 29. 435-442 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堺 武男: "呼吸機能検査からわかる病態" Neonatal Care. 10. 536-541 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堺 武男: "新生児の人口換気療法" 今日の治療指針. 752- (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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