• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The optimal infusion rate of medium-chain triglyceride/long-chain triglyceride emulsion (MCT/LCT) during plasma insulin clamp

Research Project

Project/Area Number 08671355
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionMie University

Principal Investigator

MIKI Chikao (1997)  Mie University Eaculty of Medicine Assistant, 医学部, 助手 (50242962)

入山 圭二 (1996)  三重大学, 医学部, 助教授 (10024754)

Co-Investigator(Kenkyū-buntansha) IRIYAMA Keiji  Mie University Eaculty of Medicine (Research Collaborator)
三木 誓雄  三重大学, 医学部, 助手 (50242962)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordslipid emulsion / medium-chain fatty acid / long-chain fatty acid / triglyceride hydrolysis / triglyceride clamp technique / insulin clamp / トリグリセライド・クランプ / インスリンクランプ / 投与速度
Research Abstract

As medium-chain triglyceride emulsions (MCT) are more rapidly hydrolyzed than long-chain triglyceride emulsions (LCT), MCT/LCT tends to be infused faster than LCT.The purpose of this research project was to determine the most appropriate infusion rate for MCT/LCT to stabilize plasma concentrations of triglyceride (TG), being equivalent to the optimal infusion rate of the emulsion. A TG clamp was set up by raising the mean (]SY.+-。[) s.d.concentrations of TG in plasma, being 1.08 (]SY.+-。[) 0.18 delta-mmol/l for LCT,and 1.65 (]SY.+-。[) 0.31 delta-mmol/l for MCT/LCT after a 50-min priming infusion of each emulsion. Thereafter, the infusion rate of lipid was controlled every 10 min to maintain a steady concentration of TG for a period of 150 min. A constant infusion of glucose at 0.32 g/kg/h was given for the test period. The weight-based rate of the infusion to maintain a steady state of plasma TG concentrations did not differ between MCT/LCT and LCT,being 0.125 (]SY.+-。[) 0.013 versus 0.117 (]SY.+-。[) 0.021 g/kg/h, while the molar-based infusion rate was 0.203 (]SY.+-。[) 0.021 mmol/kg/h for MCT/LCT and 0.132 (]SY.+-。[) 0.023 mmol/kg/h for LCT.These results suggest that although 54% more molar MCT/LCT can be hydrolyzed during a constant infusion, MCT/LCT should not be infused at a rate faster than 0.1 g/kg/h under a steady state.
Apolipoprotein C-II (apo C-II) is essential for TG hydrolysis. It was investigated in vitro if the amounts of apo C-II acquired by lipid particles are different between MCT and LCT.The results demonstrated that there was no differences in the amounts of in vitro transfer of apo C-II from high-density lipoprotein to lipid particles between MCT and LCT.However, it was suggrested that MCT-TGs require less amounts of apo C-II than LCT in the process of hydrolysis, since the mean amount of apo C-II acquired by one micro-mol of MCT-TG was less than that acquired by one micro-mol of LCT-TG.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Keiji Iriyama: "Elimination rate of fat emlsion particles from plasma in Japanese subjects as determined by a triglyceride clamp technique." Nutrition. 12. 79-82 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Keiji Iriyama: "Elimination of fat emulsion particles from plasma during glucose infusion." British Journal of Surgery. 83. 946-948 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Keiji Iriyama: "The metabolic distinctiveness of emulsified lipid particles in the bloodstream and its clinical implications." Surgery Today. 26. 673-678 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Keiji Iriyama: "Constant infusion rates of lipid emulsions to stabilize plasma triglyceride concentrations: Medium-chain triglyceride/long-chain triglyceride(MCT/LCT)versus LCT." Surgery Today. 28(3)(in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 入山 圭二: "MCT含有脂肪乳剤の代謝特性と将来展望" 医学のあゆみ. 183. 743-746 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 入山 圭二: "中鎖・長鎖混合脂肪乳剤(MCT/LCT)の至適投与速度" 日本静脈・経腸栄養研究会誌. 12. 184-186 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iriyama K,Carpentier YA.: "Clinical significance of transfer of apolipoproteins between triacylglycerol-rich particles in lipid emulsion and plasma lipoproteins." Nutrition. 10. 252-254 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iriyama K,Tsuchibashi T,Miki C,Iunga K,Li H,Urata H,Saitoh R.: "Elimination rate of fat emulsion particles from plasma in Japanese subjects as determined by a triglyceride clamp technique." Nutrition. 12. 79-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iriyama K,Tsuchibashi T,Urata H,Miki C,Ilunga K,Li H,Carpentier YA.: "Elimination rate of fat emulsion particles from plasma during glucose infusion." Br J Surg. 83. 946-948 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iriyama K.: "The metabolic distinctiveness of emulsified lipid particles in the bloodstream." Surg Today. 26. 673-678 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iriyama K,Miki C,Inoue T,Kawarabayashi N,Urata H,Shigemori C.: "Constant infusion rates of lipid emulsions to stabilize plasma concentrations ; Medium-chain triglyceride/long-chain triglyceride (MCT/LCT) versus LCT." Surg Today. 28 : no.3(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iriyama K.: "Metabolic distinctiveness of MCT-containing lipid emulsions and its clinical implications. (in Japanese)" IGAKUNOAYUMI. 183. 743-746 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Keiji Iriyama: "Elimination rate of fat emlsion particles from plasma in Japanese subjects as determined by a triglyceride. clamp technique." Nutrition. 12. 79-82 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keiji Iriyama: "Elimination of fat emulsion particles from plasma during glucose infusion." British Journal of Surgery. 83. 946-948 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keiji Iriyama: "The metabolic distinctiveness of emulsified lipid patricles in the bloodstream and its clinical implications." Surgery Today. 26. 673-678 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keiji Iriyama: "Constant infusion rates of lipid emulsions to stahilize plasma triglyceride concentrations: Medium-chain triglyceride/long-chain triglyceride(MCT/LCT)versus LCT." Surgery Today. 28(3)(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 入山圭二: "MCT含有脂肪乳剤の代謝特性と将来展望" 医学のあゆみ. 183. 743-746 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 入山圭二: "中鎖・長鎖混合脂肪乳剤(MCT/LCT)の至適投与速度" 日本静脈・経腸栄養研究会誌. 12. 184-186 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keiji Iriyama: "Elimination rate of fat emlsion particles from plasma in Japanese subjects as determined by a triglyceride clamp technique." Nutrition. 12. 79-82 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Keiji Iriyama: "Elimination of fat emulsion particles from plasma during glucose infusion." British Journal of Surgery. 83. 946-948 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Keiji Iriyama: "The metabolic distinctiveness of emulsified lipid particles in the bloodstream and its clinical implications." Surgery Today. 26. 673-678 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 入山圭二: "中鎖・長鎖混合脂肪乳剤(MCT/LCT)の至適投与速度" 日本静脈・経腸栄養研究会誌. 12. 184-186 (1997)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi