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Cell dynamics from the viewpoint of cell proliferation and cell death in several hereditary intestinal polyposis syndrome.

Research Project

Project/Area Number 08671417
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionSasaki Institute (1997)
Tokyo Medical and Dental University (1996)

Principal Investigator

IWAMA Takeo  Sasaki Institute, Fellow, 外科, 研究員 (70114741)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsFamilial adenomatous polyposis / Juvenile polyposis / Peutz-Jeghers syndrome / Cell proliferation / Apoptosis / アポートシス / 大腸癌 / 遺伝性消化管腫瘍
Research Abstract

The patients included 15 adenomas in FAP(familial adenomatous polyposis), 3 Juvenile polyposis, 5 Peutz-Jeghers syndrome, 14 sporadic adenomas, 46 sporadic colorectal carcinomas and 20 normal colorectal epithelium. The specimen were processed for TUNEL(terminal uridine deoxyuncleotide nick end labeling)and PCNA(proliferating cell nuclear anatigen)staining. Adenomas showed high PCNA and TUNEL indices compared to the normal epithelium. There were no differences in TUNEL and PCNA indices between adenomas of FAP and sporadic adenomas. Juvenile polyposis showed no TUNEL and PCNA positive cells. Peutz-Jeghers syndrome showed high PCNA indices and normal TUNEL indices. Carcinoma showed higher PCNA and TUNEL indidces was useful in refleclting difference of cell proliferation between differnt hereditary conditions.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 張 燕革、岩間 毅夫、他: "遺伝性消化管腫瘍性疾患における腫瘍の増殖と細胞死からみた増殖動態の解析" 日本消化器外科学会雑誌. 50(6). 1446 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yange Zang, Takeo Iwama et al: "Histochemical study of opoptosis and cell proliferation in hereditory intestinol diseases." Journal of Medical and Pental Sciences. 45(2)(in printing). (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yange Zang, Takeo Iwama, et al.: "Cell dynamics from the viewpoint of cell proliferation and cell death in sefveral hereditary intestinal polyposis syndrome." Jpn J Gastroent Surg. 50(6). 1446 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yange Zang, Takeo Iwama, et al.: "Histochemical study of poptosis and cell proliferation in hereditary intestinal diseases." Journal of Medical and Dental Sciences. 45(2)(in printing). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 張燕革, 岩間毅夫,他: "遺伝性消化管腫瘍性疾患における腫瘍の増殖と細胞死からみた増殖動態の解析" 日本消化器外科学会雑誌. 50(6). 1446 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yange Zang, Takeo Iwama,et al.: "Histochemical study of apoptosis and cell proliferation in hereditary intestinal diseases." Journal of Medical and Dental Sciences. 45(2). 65-70 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 張燕華,岩間毅夫: "大腸癌におけるアポートシス発現の検討" 日本大腸肛門病学会雑誌. 49. 807- (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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