| Project/Area Number |
08671426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKAHASHI Yutaka Kanazawa University, Cancer Research, Institute Surgery, Associate Professor, がん研究所, 助教授 (10179541)
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| Project Period (FY) |
1996 – 1997
|
| Project Status |
Completed (Fiscal Year 1997)
|
| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
|
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| Keywords | gastric cancer / angiogenesis / VEGF / PD-ECGF / 血管新生因子 / 転移 |
|---|
| Research Abstract |
Angiogenesis is essential for tumor growth and metastasis and depends on the production of angiogenic factors by host and/or tumor cells. We studied the role of angiogenesis and angiogenic factors in human gastric cancer. Vascular endothelial growth factor (VEGF), one of angiogenic factors, was produced by tumor cells and was a responsible factor for the induction of angiogenesis in intestinal-type gastric cancer. And platelet derived endothelial cell growth faftor (PD-ECGF), another angiogenic factor, was kexpressed in infiltrating cells and correlated with VEGF expression in tumor cells. Angiogenesis was greater in tumors with both high VEGF and PD-ECGF expression than those with high expression of either factor alone. These results suggest that multiple angiogenic factors expressed by both tumor cells and infiltrating cells may play a role in eegulation of angiogenesis in intestinal-type gastric cancer.
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