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Apoptosis as a prognostic factor in colorectal carcinoma.

Research Project

Project/Area Number 08671443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTottori University

Principal Investigator

MAKINO Masato  Tottori University Hospital, Assistant Prof., 医学部・附属病院, 講師 (90229344)

Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsapoptosis / colorectal carcinoma / prognosis / Ki-67
Research Abstract

We investigated the occurrence of apoptotic cell death in 104 colorectal carcinomas byterminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling (TUNEL) in order to examine whether or not apoptosis might be useful as a prognostic factor. An apoptotic index (AI) was caluculated as the percentage of positine cancer cells per 1,000 cancer cells. The median value of AI was 4.1 (range, 1.9-4.7). Apoptosis was less frequently-observed in tumors with higher malignannt potential, such as tumors at advanced stages (Dukes B,C and D), than at Dukes A (p<0.05), and it was less frequent in tumors with evidence of moderate differentiation than in those with evidence of well differentiation (p<0.05). It was also less frequent in tumors with venous invasion or lymph node metastasis than in those without these features (p<0.05). Moreover, the subgroup with a high AI in tumors at Dukes stage C (five-year survival rates were 33% vs. 68%, p<0.05 ; Cox-Mantel). Our findings suggest that less apoptosis might result in greater progression of colorectal carcinomas and the rate of apoptosis might be one of the indicators of the degree of malignancy. Moreover, it appears that the frequency of apoptosis in tumor cells might be useful prognostic factor in colorectal carcinoma.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] K.Sugamura, et al.: "Enhanced induction of apoptosis of human gastric carcinoma cells after preoperative treatment with 5-fluorouracil." Cancer. 79. 12-17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 木村 修, ほか: "フローサイトメトリーを用いた大腸癌ならびに大腸腺腫におけるアポトーシスの検討" 日本消化器外科学会雑誌. 30. 969-974 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 牧野 正人, ほか: "術前5-FU投与によるヒト胃癌・大腸癌におけるapoptosis増加" Biotherapy. 12. 107-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Sugamura, et al.: "Apoptosis as a prognostic factor in colorectal carcinoma." Surgery Today. (in print).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kimura, O et al.: "Flow Cytometric Analysis of Apoptosis in Colorectal adenomas and carcinomas." Jap J of Gastroenterol Surgery. 30. 969-974 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sugamura, K et al.: "Apoptosis as a prognostic factor in colorectal carcinoma." Surgery Today. (in print).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Sugamura, et al.: "Enhanced induction of apoptosis of human gastric carcinoma cells after preoperative treatment with 5-fluorouracil." Cancer. 79. 12-17 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 木村 修, ほか: "フローサイトメトリーを用いた大腸癌ならびに大腸腺腫におけるアポトーシスの検討" 日本消化器外科学会雑誌. 30. 969-974 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 牧野正人, ほか: "術前5-FU投与によるヒト胃癌・大腸癌におけるapoptosis増加" Biotherapy. 12. 107-109 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Sugamura, et al.: "Apoptosis as a prognostic factor in colorectal carcinoma." Surgery Today. (in print).

    • Related Report
      1997 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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