| Project/Area Number |
08671447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yamaguchi Univeristy |
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Principal Investigator |
NISHIDA Minekatsu Yamaguchi University School of Medicine Hospital.Assistant, 医学部・附属病院, 助手 (80243666)
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| Co-Investigator(Kenkyū-buntansha) |
前田 義隆 山口大学, 医学部, 助手 (30291488)
清水 良一 山口大学, 医学部・附属病院, 助手 (30187471)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Liver failure / hepatectomy / plasmapheresis / LCAT / Hyaluronic acid / Cytokine / IL-6 / Endotoxin / 肝切除術 / IL-Ira / IL-8 / Alka phospase ratio |
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| Research Abstract |
The correct management of postoperative hepatic failure following heaptectomy depends on an understanding of the mechanisms behind these abnormalities both to prevent the development of multiorgan failure and to optimally manage patients in whom some organ damage has already developed. However, the onset of the postoperative hepatic failure following hepatectomy usually proceed to multiorgan failure, maybe due to liver to other organ interaction. Thus, patients in whom excessive hepatectomy were carried out, were treated by a hemofiltration using the EVAL secondary membrane filers to remove inflammatory mediators on first postoperative day. Dramatic improvements were seen in hepatic parameters, and the effects were lasting for several days, even though the hemofiltration had been carried out only one day. These resulsts suggested that the hemofiltration using the EVAL secondary membrane filers removed inflammatory mediators on first postoperative day after hepatectomy.
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