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MECHANISTIC ANALYSIS AND ENHANCEMENT OF CELL DEATH OF HUMAN PANCREATIC CANCER CELL LINE EXPOSED BY HIGH DOSE X-RAY IRRADIATION - FOR THE IMPROVEMENT OF ADJUVANT CHEMOTHERPY OF PANCREATIC CANCER

Research Project

Project/Area Number 08671457
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MIZUMOTO Kazuhiro  KUSHU UNIVERSITY,ASSISTANT PROFESSOR, 医学部, 助手 (90253418)

Co-Investigator(Kenkyū-buntansha) TANAKA Masao  KYUSHU UNIVERSITY,PROFESSOR, 医学部, 教授 (30163570)
SHIMURA Hideo  FUKUOKA UNIVERSITY,AASOCIATE PROFESSOR, 医学部, 助教授 (80178996)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
KeywordsPANCREATIC CANCER / RADIATION / APOTOSIS / RADIATION ENHANCEMENT
Research Abstract

Effect of etoposide on the cell deaths of a human pancreatic cancer cell line by exposure to high dose X-ray irradiation was examined. Both high dose X-ray irradiation and etoposide killed the pancreatic cancer cells by apoptosis. With 30 gray irradiation, simultaneous treatment of etoposide did not alter the percentage of cell deaths ; however, 24-hr prior treatment of etoposide killed a significantly larger percentage of the cells, accompanying the accumulation to the S phase of the cell cycle. The results indicates that apoptosis of human pancreatic cancer cell line induced by high dose X-ray irradiation can be enhanced by the prior treatment of etoposide.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 水元 一博、他: "膵癌に対する大量X線照射とEtoposideの併用効果" 癌と化学療法. 23. 1673-5 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 郭 錦秋、水元 一博、他: "大量X線照射によるヒト膵・胆嚢癌培養細胞株のアポトーシス" 膵臓. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mizumoto K,et al.: "Effect of etoposide on a human pancreatic cancer cell line exposed by high dose X-ray irradiation." Japanese Journal of Cancer Chemotherapy. 23(12). 1673-1675 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Guo J,Mizumoto K,et al.: "Apoptosis of Pancreas and Gall Bladder Cancer Cells Induced by a High Dose X-ray Irradiation." Journal of the Japan Pancreas Society. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 水元一博 他: "膵癌に対する大量X線照射とEtoposideの併用効果" 癌と化学療法. 23(12). 1673-5 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 郭錦秋、水元一博 他: "大量X線照射によるヒト膵・胆嚢癌培養細胞株のアポトーシス" 膵臓. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] 水元一博、他: "膵癌に対する大線量X線照射とEtoposideの併用効果" 癌と化学療法. 23(12). 1673-5 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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