| Project/Area Number |
08671470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KITAMURA Kazuya Kyoto Prefectural University of Medicine. Surgery I,Assistant., 医学部, 助手 (10224966)
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| Project Period (FY) |
1996 – 1997
|
| Project Status |
Completed (Fiscal Year 1997)
|
| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Early gastric cancer / Monoclonal antibody / Radioisotope / Surgery / リンパ節転移 |
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| Research Abstract |
This study was designed to determine the clinical effectiveness of 131-I rabeled human mouse chimeric monoclonal antibody A7 for radioimmunogided surgery. The radiolabed antibody was administered iv to 11 patients with gastric or colorectal cancer 3 days before surgery. Gamma detection probe was used for identifying target tumor. In eigth patients, primary tumor was identified intraoperatively and in two patients, lymph node metastasis was found. This result indicates that although monoclonal antibody is a promising tool for enhancing the effectiveness of monoclonal antibody A7 in radioimmunoguided surgery.
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