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Effects of various cytokines on gastrin secretion, and relation between cancer proliferation and gastrin or its receptor

Research Project

Project/Area Number 08671483
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTokai University

Principal Investigator

MIYAJI Masao  Tokai University, School of Medicine, Instructor, 医学部, 助手 (90219783)

Co-Investigator(Kenkyū-buntansha) TANI Norio  Tokai University, School of Medicine, Assistant Professor, 医学部, 助教授 (20096241)
OGOSHI Kyoji  Tokai University, School of Medicine, Associate Professor, 医学部, 助教授 (30112775)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsgastrin / gastrin receptor / gastric cancer / cytokine / G-cell / IL-1 B / TNF-alpha / IL-8 / IL-IB / IL-8 / IL-1β / TNFーα / 悪性度 / 増殖能(増殖因子) / 癌遺伝子 / 予後 / 発癌
Research Abstract

Under this Grant in Aid for Scientific Research, we have clinically confirmed as follows, 1) The initiation and proliferation in early gastric cancer were affected by the environment of hypergastrinemia in aging. 2)The prognosis of patients with hypergastrinemia was significantly worse than those with low gastrinemia, especially in the patients with poorly differentiated gastric cancer. 3)The expression of c-erbB-2, EGFR, PCNA and Ki-67 in the patients with hypergastrinemia were significantly more frequently than those with 1ow gastrinemia. Furthermore, we evaluated whether or not the expression of gastrin receptor gene exists in gastric cancer by using RT-PCR method, and as a result the expression rate of the gene was 10.6% (5/47). We speculated that the expression of the receptor affected either tumor proliferation or metastasis from the clinicopathological examination. Finally, after we established the system of G-cells primary culture from guinea-pig's stomach, we found the inflammatory cytokines , such as IL-lbeta, TNF-alpha and IL-8, stimulated gastrin production and secretion from G-cells. These results suggest that endogenous hypergastrinemia may play an important role in pathophysiology of gastric cancer.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Masao Miyaji et al: "Gastric acid secretion aad serum gastria levels in gastric cancer." Receat Advances in Marapeneat of Digestive Cancers. 1. 230-232 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji et al: "Serum gastria levels in gastric cancer" Biomedical Research. 15. 405-409 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 宮治 正雄, 他: "ガストリン分泌動態と胃癌の病態" Progress in Medicine. 16. 863-86〓 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 宮治 正雄,他: "胃癌患者における血清ガストリン値測定の臨床的意義-胃癌の病態・予後との関連において-" 消化器科. 22. 344-351 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Association between serum gastrin levels, gastric acid secretion and age in easty gastric cancer." Tumor Biology. 18. 311-320 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Effects of various cytokines on isolated guinea pig G-cells and gastrin" Gastroeaterology. 114. G4767 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Clinical significance of serum gastria values in gastric cancer patients" E.Passaro Jr.et al. Moaduzzi Editzre, 161-165 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Gastrin aad gastric carciaogea Receat Advances in Gastroeaterological Carcinogenesis I." E.Tahara, et al Morduzzi Editore,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 307-310 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masao Miyaji, et al: "Gastric acid secretion and serum gastrin levels in gastric cancer." Recent Advances in Management of Digestive Cancers. T.Takahashi ed.Springer-Verlag. 230-232 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Serum gastrin levels in gastric cancer." Biomedical Research. 15 (Suppl). 405-409 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masao Miyaji, et al: "Serum gastric levels and pathophysiology in gastic cancer." Progress in Medicine. 16. 863-866 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masao Miyaji, et al: "The relationship between serum gastrin levels and pathophysiology prognosis in gastric cancer." Gastroenterology. 22. 344-351 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Association between serum gastrin levels, gastric acid secretion and age in early gastric cancer." Tumor Biology. 18. 311-320 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Effects of various cytokines on isolated guinea pig G-cells and gastrin." Gastroenterology. 114 part 2. G4767 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Clinical significance of serum gastrin values in gastric cancer patients. In : E.Passaro Jr.et al, eds.Collegium internationle Chirurgiae Digestivae 14th World Congress, Bologna : Monduzzi Editore" 161-165 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji, et al: "Gastrin and gastric carcinogen. Recent Advances in Gastroenterological Carcinogenesis I." E.Tahara, K.Sugimachi, T.Oohara eds Monduzzi Editore, Bologna. 307-310 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Miyaji: "Effects of various cytokines on isolated guinea pigG-cells and gastrin" Gastroerterology. 114・4. A1165 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Miyaji: "EFFECTS OF VARIOUS CYTOKINES ON ISOLATED GUINEA PIG G-CELLS" Oigestion. 59-sup3. 242 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masao Miyaji: "Association between sercen gastria levels,gastricacid secretion aad age in party gasiric carcet" Tunor Biology. 18. 311-320 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 宮治正雄: "ガストリン分泌動態と胃癌の病態" Progress in Medicine. 16・3. 863-866 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮治正雄: "胃癌患者における血清ガストリン値測定の臨床的意義-胃癌の病態・予後との関連において-" 消化器科. 22・4. 344-351 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Miyaji: "Gastrin and gastric carcinogenesis" Recent Advances in Gastroenterological Carciragenesis. 1. 307-310 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮治正雄: "試験食負荷後血清ガストリン分泌反応と胃癌患者の予後" 消化管ホルモン(XIV). 14. 47-49 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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