| Project/Area Number |
08671487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Univ.Toho, Japan |
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Principal Investigator |
YOSHIO Toshofumi Toho Univ.1st.Dep.Sarg.Protessor, 医学部, 教授 (80057497)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroshi Toho Univ 1st.Dep.Sarg.Assifant, 医学部, 助手 (60207909)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1997: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
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| Keywords | FISH / Colorectal cancer / biological malignaney / namerical chromosome abrerration / FISH(Fluorescence in situ hybridization) / 腫瘍内異質性 |
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| Research Abstract |
We studied the value of biological malignancy in human colorectal cancer of mumerical chromosome abrerrations There are many indications of biological malignancy in human colorectal cancer. For example in clinicopathological findings, histological type, lymph node metastasis, vessel invasion and so on. Recently, in addition to clinicopathological findings, biogenetic engneering has been used. We has used flow cyfo metry and immunohistochemistry. So aneuploid pattern and high activity of proliferation. But those are not defined. So we fried to ualue the malignant pofenfial in single cell neucleus about numerical chromosome aberarration, the activity of proliferation and histological model, using fISH method of biogenetic engneering and method of immunonisfochemistry. But problem of intricate technige was listed up. So we could observed only a little area in paraffined slideand could not counfed. We continue to try fo modify fechnige easily
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