Project/Area Number |
08671500
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Kurume University |
Principal Investigator |
SAITSU Hideki Kurume Univ., Sch.of Med., Assist. Prof., 医学部, 講師 (60186921)
|
Co-Investigator(Kenkyū-buntansha) |
IMAI Yasuhisa Kurume Univ., Sch.of Med., Instructor, 医学部, 助手 (90268847)
NAKAO Masanobu Kurume Univ., Sch.of Med., Instructor, 医学部, 助手 (40258447)
|
Project Period (FY) |
1996 – 1997
|
Project Status |
Completed (Fiscal Year 1997)
|
Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
|
Keywords | HCC / CTL / MHC-nonrestriction / tumor-rejection antgens / 癌退縮抗原 |
Research Abstract |
We investigatet T Cell immunity against hepatocellular carcioma (HCC), and showed that both peripheral blood mononuclear cells (PBMC) and tumor-infiltrating lymphocytes (TIL) incubated with ingterleukin-2 alone displayd HHLA-nonrestricted but hepatic cancer-specific cytotoxicity in a majority of parients with HCC.Namely, they lysed both HCC and cholagiocellular carcinomas in an HLA-nonrestricted manner, but not any tumors with the other histological types tested, normal hepatocytes or the cells transfected with Hepatitis C virus or MUCl gene. These CTL lines and clones were phenotypically CD3^+CD4^+CD8^-. These unique CTL could play important riles in T cell immunity against HCC.
|