| Project/Area Number |
08671528
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama university |
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Principal Investigator |
ANDOU Akio Okayama University, Medical School, Associate Professor, 医学部, 助教授 (70222776)
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| Co-Investigator(Kenkyū-buntansha) |
AOE Motoi Okayama University, Medical School, Hospital, Assistant, 医学部附属病院, 助手 (80260660)
DATE Hiroshi Okayama University, Medical School, Hospital, Assistant, 医学部附属病院, 助手 (60252962)
SHIMIZU Nobuyoshi Okayama University, Medical School, Professor, 医学部, 教授 (90108150)
野崎 功雄 岡山大学, 医学部・附属病院, 医員
虫明 寛行 岡山大学, 医学部・附属病院, 医員
木下 尚弘 岡山大学, 医学部・附属病院, 医員
小森 栄作 岡山大学, 医学部・附属病院, 医員
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Lung Ventilation Scanning / Technegas / SPECT (Single Photon Emission Computed Tomography) / Measurement of Lung Volume / Prediction of Postoperative Respiratory Function |
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| Research Abstract |
We investigated the usefulness of technegas lung ventilation scanning using single photon emission computed tomography (SPECT) to measure lung volume and predict pulmonary function after lung resection. We calculated the lung volume from images obtained by technegas lung ventilation scanning using SPECT in four subjects with normal pulmonary function, and compared these values with the measured lung volume. By setting the threshold level at 15% measurement of lung volume closest to the measured values was possible. With the method of technegas lung ventilation scanning using SPECT (threshold level 15%) the following parameters of pulmonary function after lung resection were predicted : forced vital capacity (FVC), forced expiratory volume in first second (FEV_<1.0>), and maximal voluntary ventilation (MVV). In 26 lung cancer patients scheduled to undergo lung resection, prior to surgery and 1, 4 and 6 months thereafter pulmonary function tests (FVC, FEV_<1.0>, MVV) and predictions of pulmonary function after lung resection by technegas lung ventilation scanning using SPECT were done. A close correlation was noted between the predicted values of FVC and the postoperative values at 1, 4 and 6 months(r=0.720-0.797, p<0.0005). Similarly close correlations were noted between the predicted values of FEV_<1.0> (continue to next page) and MVV and the respective measured postoperative values (FEV_<1.0> : r=0.723 - : 0.792, p<0.00005 ; MVV : r=0.730-0.750, p<0.0005). Also, when the predicted values of pulmonary function obtained hitherto performed ^<99m> TcMAA lung perfusion scanning using SPIECT and by technegas lung ventilation scanning using SPECT were compared from their correlation coefficients, numerically measured postoperative values obtained by latter method showed good values, suggesting the utility of this method in the prediction of postoperative pulmonary function.
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