| Project/Area Number |
08671532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Saga Medical School |
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Principal Investigator |
ITOH Tsuyoshi Saga Medical School, Surgery, Professor, 医学部, 教授 (10110496)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Kouzou Saga Medical School, Surgery, Assistant Professor, 医学部, 講師 (20217623)
UENO Tetsuya Saga Medical School, Surgery, Assistant Professor, 医学部, 講師 (10184954)
NATSUAKI Masafumi Saga Medical School, Surgery, Associated Professor, 医学部, 助教授 (90075557)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Cardiovasunlar / Aortic valve / Valve sparing operation / Aortic root reconstruction / Sinotubular junction / Remodeling procedure / sinotublar junction |
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| Research Abstract |
1.The relationship of the sinotubular junction (STJ) with aortic regurgitaion (AR)
(1) Experimental method
Using mongrel dogs, the beating heart models were made with perfusion through the aortic root and left atrium with the Tyrode's solution. A six sutures were placed in each commissure and each sinus of Valsalva at the level of STJ.By restracting the sutures outwaeds, delatation of aortic root was simulated. While changing retraction sites, direct images of valve coaptation were recorded with endoscope. Additionally, the strain of the sutures were changed by the gravity.
(2) Result
With the increase on the strain of the sutures, the opening of the aortic valve was exaggerated when either all sutures or the commissures was retracted. In cases of the drawing only three sinuses of Valsalva, the coaptation of the aortic valve was kept uninterrupted. This study validated that the dilatation of STJ cause AR.
2.The behavior of the aortic valve under remodeling procedure
(1) Experimental method
The beating heart model was made with same method as 1-(1). Using the cardeac endoscopy and high speed video (200frames/second), the behavior of the aortic valve was investigated under noumal condition (Group 1) and the aortic root reconstruction with remodeling procedure (Group 2)
Experimental result
The pattern of the behavior of the aortic valve was almost equal between Group 1 and 2. With Group 2, the maximum opening of the aortic valve was recorded at the time of maximum aortic pressure. It was concluded that the aortic root reconstruction with remodeling procedure was valuable technique in preserving the aortic valve function.
3.Clinical experiments
To date, seven aortic root reconstructions preserving native valve were perfoumad. In six cases, the evaluation of aortic valve was performaed with endoscopy. Cardiec endoscopy was useful technique in evaluation of the etiology of the valeve imcopetence, selection of the procedure and the result of the plasty.
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