| Project/Area Number |
08671543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Showa University |
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Principal Investigator |
KADOKURA Mitsutaka Showa University, School of Medicine, Lecturer, 歯学部, 専任講師 (60214417)
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| Co-Investigator(Kenkyū-buntansha) |
TANIO Noboru Showa University, School of Medicine, Assistant, 歯学部, 助手 (90255729)
NONAKA Makoto Showa University, School of Medicine, Assistant, 歯学部, 助手 (20266117)
森保 幸治 (森保 孝治) 昭和大学, 医学部, 助手 (00255738)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Lung transplantation / Cadaveric organ transplantation / Warm ischemia / Ischemia reperfusion injury / Surfactant / Low flow reperfusion / Rabbit / Rat / 虚血再潅流 / 希釈血液潅流 / 肺静脈圧 / NO / 肺静脈フラッシュ / 肺保存 / 病理組織学的検討 / 温阻血後再灌流障害 / 低流量再灌流 / サーファクタント投与 / 心停止後温阻血 / LPD灌流 / 中毒死(薬物死) / 急速脱血 |
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| Research Abstract |
The most serious obstacle to more widespread use of lung transplantation is the limited size of the pulmonary donor pool. Despite the realization that lung transplantation from a non-heart-beating cadaveric donors clinically feasible, the procedure has not received wide acceptance. We studied the effects of flush height, magnesium, reperfusion flow rate, initial low flow reperfusion, surfactant, low Ht, high pulmonary venous pressure, NO, and pulmonary venous heparin flush. The low flush height and low reperfusion flow rate were effective.. Though magnesium or surfactant administration was lowered the lung edema. The initial low flow reperfusion and pulmonary venous flush decreased the graft failure. These methods improved the cadaveric lung function.
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