Detection of genetic aberrations in early-stage lung cancer by fluorescence in situ hybridization
| Project/Area Number |
08671545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
NAKAMURA Haruhiko Tokyo Medical University, Medicine, Assistant Professor, 医学部, 講師 (80183523)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Harubumi Tokyo Medical University, Medicine, Professor, 医学部, 教授 (20074768)
KONAKA Chimori Tokyo Medical University, Medicine, Associate Professor, 医学部, 助教授 (70147180)
SAITO Makoto Tokyo Medical University, Medicine, Assistant Professor, 医学部, 講師 (30225734)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | oncogene / lung cancer / early-stage lung cancer / in situ hybridization |
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| Research Abstract |
Genetic aberrations in lung cancer cells were examined using fluorescence in situ hybridization (FISH) concerning the p53 and erbB2 gene loci. Deletions of the p53 locus were detected in 5/28(17.6%) and amplifications of the erbB2 locus were detected in 8/28(28.6%). Both aberrations were detectable even in stage I cases. We concluded that peripheral type small size lung cancers without regional lymph node metastases often carried genetic changes as early events. Accumulation of those mutations may develop malignant phenotype of the tumor. One of the advantages of FISH analyes is to get genetic information of lung cancers by needle biopsy preoperatively. FISH may contribute to select operation methods according to the grade of genetic aberrations.
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Report
(4 results)
Research Products
(6 results)
