| Project/Area Number |
08671549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
KAWANA Hideyo Tokyo Women's Medical College, Surgery I,asistant, 医学部, 助手 (20201444)
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| Co-Investigator(Kenkyū-buntansha) |
OHNUKI Takamas Tokyo Women's Medical College, Surgery I,vice professor, 医学部, 助教授 (20194235)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | artifical rogan / diaphragma / phrenic nerve palsy / ventilatory disturbance |
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| Research Abstract |
This study is a basic research for the develope of artificial diaphragma (we call DAS (Diaphragma Asist System)). It wil be benefit for treatment of phrenic nerve palsy and neuro-musculer disease. Our system press down the diaphragma by paddle toward the abdominal cavity. Experiments were carried out on anesthetized dogs.
Preliminary Experiments : The paddle's fulcrums of DAS were directly attached to posterior parts of bilateral 10th ribs. and Tension generator pulled down the anterior part of paddle. But it is not successed. For generated large negative pressure in thorax moved ribs inward, the deflated ribs impeded movement of paddle.
Experiment : Follwing preliminary experiments, we covered around the paddle of DAS by case. The case was fixed to 7th ribs, and paddle's fulcrums were connected by hinge with posterior part of case. Paddle were pull down by tension generator in a same way of preliminary experiment.
Result : Our DAS performed Maximum expiratory flow = 300 ml/s, Tidal volume = 170 ml, generated pressure = 50mmHg. The paddle of our DAS can be actively push up at the expiratory period. But it was not need.
Conclusion : Diaphragma Asist System (DAS) can be realized. It is useful for develope of small tension generator that any force is not need at expiratory period.
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