| Project/Area Number |
08671560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
SAKO Kazuhiro Asahikawa Medical College, Neurosurgery, Instructor, 医学部, 講師 (80113736)
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| Co-Investigator(Kenkyū-buntansha) |
遠山 義浩 旭川医科大学, 医学部, 助手 (70261419)
米増 祐吉 旭川医科大学, 医学部, 教授 (30038666)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | hypothermia / cerebral blood flow / glucose metabolism / nitric oxide / adenosine / Autoradiography rat / NO / rat |
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| Research Abstract |
We measured regional cerebral blood flow and glucose metabolism in normothermia and hypothermia. We also measured nitric oxide and adenosine by microdialysis.
Temperature of parietal cortex and caudate nucleus at 37ﾟC (rectal temperature) was 36.5*0.3ﾟC and 36.7*0.2ﾟC respectively, When the body temperature was kept at 30ﾟC, temperature of parietal cortex and caudate nucleus decreased to 29.1*0.2 and 29.6*0.3ﾟC respectively. Blood pressure decreased slightly at 30ﾟC compared with normothermia but was not significant. During hypothermia, regional cerebral metabolic rate of glucose (CMRglu) decreased with relatively uniform rates, ranging from 40% to 55%. There was no significant difference between cerebral cortex and deep-seated nucleus in reduction rates. Regional cerebral blood flow (CBF) of 9 structures during normothermia and hypothermia was compared. CBF decreased significantly in all brain regions during hypothermia, but the reduction rates were variable, ranging from 19-49%. Mean CBF reduction rates in cortex and deep-seated nucleus were 24.2% and 41.6% respectively. Nitric oxide (NO) products decreased during hypothermia but was not significant statistically compared with that of normothermia. However, concentration of adenosine revealed a significant reduction during hypothermia. The magnitude of decrease in adenosine during hypothermia was significant in deep-seated nucleus.
We conclude that CMRglu decreases relatively uniform during hypothermia but CBF dose not decrease in parallel to CMRglu. CBF during hypothermia seems to be regulated by some factors and adenosine is maybe one of these factors.
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