| Project/Area Number |
08671564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | CHIBA UNlVERSITY |
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Principal Investigator |
YAMAKAMI Iwao Chiba University School of medicine, Asst Prof, 医学部, 講師 (90241968)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Motoo Chiba University Hospital : Res.Assoc, 医学部, 助手 (10225211)
IKEHIRA Hiroo Chiba University Hosptal, ASSOC : Prof, 医学部, 講師 (50150313)
KITAHARA Hiroshi Chiba University Hospital : Prof, 医学部, 教授 (30114268)
YAMAURA Akira Chiba University School of medicine : Prof, 医学部, 教授 (40009717)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | fluid percusson injury / brain edema / MRI / blood brain barrier / experimental brain injury / diffusion weighted MRI / magnetic resonance spectroscopy / horseradish peroxidase |
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| Research Abstract |
The objective of this study was to use diffusion-weighted magnetic resonance imaging to help detect the dynamics of brain edema that develops after experimental brain injury and brain injury coupled with decompressive craniectomy.
(materials and methods)
Fluid percussion brain injury was induced in sixty adult Wister rats.After injury we monitored the brain edema by using T1, T2 weighted imaging and diffusion-weighted magnetic resonance imaging. These MR images were compared with pathological findings
(Results)
The information obtained by diffusion-weighted magnetic resonance imaging at acute phase of brain injury (30min after injury) reflected the damage of blood brain barrier observed by pathological findings using horse-radish peroxidase. At acute phase of brain injury diffusion-weighted magnetic resonance imaging provides us useful information about the damage of blood brain barrier.
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