| Project/Area Number |
08671569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
ENDO Shunro TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY,DEPARTMENT OF NEUROSURGERY,ASSOCIATE PROFESSOR, 医学部, 助教授 (70125269)
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| Co-Investigator(Kenkyū-buntansha) |
KUWAYAMA Naoya TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY,DEPARTMENT OF NEUROSURGERY,ASSISTAN, 医学部・附属病院, 講師 (30178157)
赤井 卓也 富山医科薬科大学, 医学部, 助手 (50222500)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | intracranial artery / wall dissection / dissecting aneurysm / vasa vasorum / intra-wall hemorrhage / atherosclerosis / pathology / cerebral artery / dissecting aneurysm / intramural hemorrhage / vasavasorum / elastin / pathogenesis / vaso vasorum / elestin |
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| Research Abstract |
This research is a clinicopathological and experimental study to investigate characteristic features and pathogenesis of the cerebral artery dissection, especially focusing on development and disruption of the intra-arterial wall vasa vasorum, The following results were revealed and presented in som papers.
# Clinicopathological study : Histopathological studies of the lesions of the intracranial dissecting aneurysm and atherosclerotic occlusive disease of the carotid artery were studied. In these diseases of the different clinical categories, the following common findings were revealed ; 1)intra-arterial wall hemorrhage associated with rich development of the vasa vasorum in the media, 2)findings showing wall-disruption of the vasa vasorum communicating with intra-wall hemorrhage, 3)advanced and localized atherosclerotic changes around these lesions.
Judging from these pathological findings, significance of advanced atherosclerotic changes with abnormal development of the vasa vasorum in the media were suspected to be a causative factor of the arterial wall dissections. Clincal study for true diagnosis and treatment of the intracranial dissecting aneurysms were also performed based on these pathological studies.
# Experimental study : Production of the animal model of advanced atherosclerosis with development of the vasa vasorum were tried, but this purpose were not succeed. We would like to continue and accomplish the experimental studies.
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