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Specific Imaging and Intracellular Hyperthermia for Brain Tumor using Magnetite Particle conjugated with monoclonal antibody

Research Project

Project/Area Number 08671574
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNagoya University

Principal Investigator

WAKABAYASHI Toshihiko  School of Medicine, Nagoya University, Assistant Professor, 医学部, 講師 (50220835)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Jun  School of Medicine, Professor, 医学部, 教授 (40158449)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsMagnetite / Glioma / Imaging / Hyperthermia / Liposome / MRI / 造影剤 / グリオーマ
Research Abstract

In this study, it was demonstrated that magnetite particle coupled to G-22 monoclonal antibody, could be useful for brain tumor imaging on MRI.After injection of this magnetite, tumor bearing mice were exposed to the magnetic field of an MRI scanner and T2 WI intensity in the tumor was compared with reference number. Result indicated a significant decreace of T2 WI intensity ratio in the tumor, suggesting specific accumulation of magnetite in the tumor. To the next study, we have investigated the possibility of hyperthermia for the tumor using this taregt directed magnetite in the high frequent magnetic field. When 375 Oe of magnetic field and 120kHz of frequency were applied, the magnetite in the tumor tissue were stimulated to be enough for heating tumor tissue to induce necrosis. These result suggest that target directed magnetite is expected to be not only for tumor enhancement agent in MRI, but also for the treatment strategy by hyperthermia for the tumor in the high frequent magnetic field.

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 若林俊彦、他: "機能性磁性微粒子を用いた脳腫瘍特異的画像診断及び温熱療法の開発" 神経免疫研究. 11. 140-145 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yanase M,et al: "Intracellular Hyperthermia for Cancer using magnetite Cationic Liposomes : An in virt study" Jpn.J.Cancer Res.89. 463-469 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yanase M,et al: "Antitumor Immunity Induction by Intracellular Hyperthernia using Maynetite Cationic Lipsomes." Jpn.J.Cancer Res.89. 775-782 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 新海政重、他: "機能的磁性微粒子を用いた脳病変部に対する新しい磁気センシング法の開発" 化学工学論文集. 24(2). 174-178 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Toshihiko Wakabayashi, et al: "Specific imaging and intracellular hyperthermia for brain tumor using magnetite particle" Neuroimmunological Research. Vol 11. 140-145 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mitsugu Yanase, et al: "Intracellular hyperthermia for cancer using magnetite cationic liposomes : an in vivo study" Jpn.J.Cancer Res.Vol 89. 463-469 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mitsugu Yanase, et al: "Antitumor immunity induction by intracellular hyperthermia using magnetite cationic liposomes" Jpn.J.Cancer Res.Vol 89. 775-782 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masashige Shinkai, et al: "Development of novel magnetite sensing for brain lision using functional magnetic particles" KAGAKUKOUGAKU RONNBUNNSHI. Vol 24(2). 174-178 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 若林俊彦 他: "機能性磁性微粒子を用いた脳腫瘍特異的画像診断及び温熱療法の開発" 神経免疫研究. 11. 140-145 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanase M. et al.: "Intracellular Hyperthmia for Cancer using Megnetite Cationic Liposomes : An in two study" Jpn.J.Cancer Res.89. 463-469 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanase M. et al.: "Antitemor lmmity Induction by Intracllular Hyperthermin using Nagnetite Cationic Liposomes" Jpn.J.Cancer Res.89. 775-782 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 新海政重, 他: "機能的磁性微粒子を用いた脳病変部に対する新しい磁気センシング法の開発" 化学工学論文集. 24(2). 174-178 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 若林俊彦,他: "モノクローナル抗体結合マグネタイトによる特異的脳腫瘍画像診断への応用" Imervision. 12(8). 30 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Uchiyama.T, et al.: "Position sensing of magnetite gel using MI sensor for fain tumor detectins." IEEE Transactions on magnetics.33(5). 4266-4268 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yanase M, et al.: "Intracellular Hyperthermia for Cancrusing Magnetite Cationic Liposomes.Exvivostudy" Jpn.J.Caneer Res.88. 630-632 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki H,et al: "Development of a target-directed magnetic resonance contrast agent using monulonal antibody-conjugated magnetic partiles" Brain Tumor Pathol. 13. 127-132 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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