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Surgical Indication for Neuroendoscopic Ventriculostomy and Local Fine ICP Dynamics/CSF Flow Dynamics

Research Project

Project/Area Number 08671618
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTokai University

Principal Investigator

OI Shizuo  Tokai University, School of Medicine, Associate Professor, 医学部, 助教授 (30194062)

Co-Investigator(Kenkyū-buntansha) TSUGANE Ryuichi  Tokai University, School of Medicine, Professor, 医学部, 教授 (70022902)
SHINODA Masaki  Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (70196393)
MATSUMAE Mitsunori  Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (20209604)
日高 充  東海大学, 医学部, 助手 (90256123)
竹井 太  東海大学, 医学部, 講師 (00216839)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1998: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsCSF dynamics / ICP dynamics / Hydrocephalus / LOVA / Neuroendoscope / Ventriculostomy / Cine-MRI / NPH / Neuroendoscope / 頭蓋内圧 / 脳腫瘍 / 脳室開放術 / 髄液循環 / 神経内視鏡手術
Research Abstract

Although the neuroendoscopic surgery, especially for treatment of non communicating hydrocephalus, has been widely applied, the definitive indication for and preoperative evaluation for postoperative efficacy remain the future subjects in hydrocephalus research. Neuroendoscopic surgery was used to treat patients with various forms of hydrocephalus with specific pathophysiology, including long-standing overt ventriculomegaly in adult (LOVA), isolated unilateral hydrocephalus (IUH), isolated fourth ventricle (11W), disproportionately large fourth ventricle (DLFV), isolated rhombencephalic ventricle (IRV), isolated quarto-ventriculomegaly (IQV), dorsal sac in holoprosencephaly (DS), and loculated ventricle (LV). The characteristics of the cerebrospinal fluid (CSF) dynamics in the individual specific pathophysiologies were delineated by cardiac-gated cine-mode magnetic resonance imaging (MM) before and after the endoscopic procedure. The postoperative changes of ventriculomegaly were compl … More icated, reflecting the difference in the brain parenchymal compliance and postoperatively corrected CSF flow dynamics in the major CSF pathway. LCP dynamics, usually in a relatively acute or subacute period in secondary hydrocephalus, the brain parenchymal compliance is well preserved. Small amount of CSF withdrawal by the shunt may normalize the high amplitude of pressure waves (HCA Stage-III). In contrast, a low- or extremely-low-pressure system may be necessary in the stage of relatively low ICP level. The compliance is lost and usually pulse pressure is small in range, with relatively low baseline pressure. (late HCA Stage-Ill and HCA Stage-IV). In these stages, a shunt system should delete the pressure waves ranging in a mildly abnormally high or even within a normal but relatively high ICP level.
The results obtained from this project in 1996-1998 included
1) The first trial and established concept of "Experimental Animal Neuroendoscopy", 2) Analyses of the local fine ICP dynamics/CSF flow dynamics, 3) Proposal of new concepts of hydrocphalus, i.e., LOVA, True NPH, hydrocephalic dementia (HD) in adult hydrocephalus, and 4) Established neuroendoscopic surgical technique and indication for ventriculostomy. Less

Report

(4 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] OiS, Hidaka M, Togo K, Matsumae M, Takei F, Sato O, Abe H, Tachiiwa M, Sasaki H, Sato Y, Suga K: "Neuro-Endoscopic Surgery (Part-3) Characteristics of Rigid, Semi-rigid and Flexible/Steerable Endoscopy : Analysis in Cadaver Dissection. Experimental Animal Model and Clinical Application." Current Tr Hyd (Tokyo). 1995 : 5. 57-66 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] OiS, Sato O, Matsumoto S: "Neurological and Medico-social Problems of Spina Bifida Patients in Adolescence and Adulthood." Child's Nerv Syst.12. 181-187 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] OiS: "Recent Advances in Neuroendoscopic Surgery : -Realistic indications and clinical achievement-" Critical Reviews of Neurosurgery. 6. 64-72 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Brinker T., Beck H., Klinge P Kischnik B., OiS., Samii M.: "Sinusoidal Intrathecal Infusion for Assessment of CSF Dynamics in Kaolin-Induced Hydrocephalus" Acta Neurochir. 140. 1069-1075 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] OiS: "Hydrocephalus chronology in adults : confused state of the terminology How should “normal-pressure hydrocephalus" be defined?" Critical Reviews of Neurosurgery. 8. 346-356 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] OiS, Hidaka M, Honda Y, Togo K, Shinoda M, Shimoda M, Tsugane R, Sato O: "Neuroendoscopic surgery for specific forms of hydrocephalus" Child's Nerv Syst. 15. 56-68 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oi S,Hidaka M,Togo K,Matsumae M,Takei F,Sato O,Abe H,Tachiiwa M,Sasaki H,Sato Y,Suga K: "Neuro-Endoscopic Surgery (Part-3) Characteristics of Rigid, Semi-rigid and Flexible/Steerable Endoscopy : Analysis in Cadaver Dissection, Experimental Animal Model and Clinical Application." Current Tr Hyd (Tokyo). 5. 57-66 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oi S,Sato O,Matsumoto S: "Neurological and Medico-social Problems of Spina Bifida Patients in Adolescence and Adulthood." Child's Nerv Syst. 12. 181-187 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oi S: "Recent Advances in Neuroendoscopic Surgery : -Realistic indications and clinical achievement-." Critical Reviews of Neurosurgery. 6. 64-72 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Brinker T., Beck H., Klinge P,Kischnik B., Oi S., Samii M.: "Sinusoidal Intrathecal Infusion for Assessment of CSF Dynamics in Kaolin-Induced Hydrocephalus" Acta Neurochir. 140. 1069-1975 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oi S: "Hydrocephalus chronology in adults : confused state of the terminology How should "normal-pressure hydrocephalus" be defined?" Critical Reviews of Neurosurgery. 8. 346-356 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oi S,Hidaka M,Honda Y,Togo K,Shinoda M,Shimoda M,Tsugane R,Sato O: "Neuroendoscopic surgery for specific forms of hydrocephalus" Child's Nerv Syst. 15. 56-68 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Brinker T.,Beck H.,KlingeP,Kischnik B.,OiS.,Samii M.: "Sinusoidal Intrathecal Infusion for Assessment of CSF Dynamics in Kaolin-Induced Hydrocephalus" Acta Neurochir. 140. 1069-1075 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] OiS: "Hydrocephalus chronology in adults:confused state of the terminology How should "normal-pressure hydrocephalus"be defined?" Critical Reviews of Neurosurgery. 8. 346-356 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] OiS,Hidaka M,Honda Y,Togo K,Shinoda M,Shimoda M,Tsugane R,Sato O: "Neuroendoscopic surgery for specific forms of hydrocephalus" Child's Nerv Syst. 15. 56-68 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 大井静雄: "中枢神経系奇形の特殊病態と外科的治療ーその最近の動向ー" Journal of Hokkaido Brain Research Foundation. 8.9巻(7). 1-7 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大井静雄: "水頭症の内視鏡下手術 2.非交通性水頭症各型における手術手技" Clinical Neuroscience. 15(11). 1294-1295 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shizuo Oi: "ーEditiorialーRecent advances and racial differences in therapeutic strategy to the pineal region tumor" Child's Nerv Syst. 14(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大井静雄: "水頭症の内視鏡下手術 1.基本操作と第三脳室開放術" Clinical Neuroscience. 15(10). 1174-1175 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大井静雄: "中枢神経系奇形の出生前診断及び出生後病態分析におけるMR Imagingの役割" Archives of Gunma Forum for Magnetic Resonance in Medicine. 7(14). 1-6 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 大井静雄: "図説脳神経外科New Approach 脳室とその近傍[機能・解剖・手術]分担執筆 III.脳室の解剖と手術 神経内視鏡による脳室形態評価と手術" メジカルビュー社, 186 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Oi S.Sato O,Matsumoto S: "Current status of pediatric skull base surgery.Special pathophysiology,surgical concept and therapeutic problems." Nervons System in Children. 21(2). 1-9 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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