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A biomechanical study on differences in the effect of stress deprivation on the in frozen extensor and flexor tendons.

Research Project

Project/Area Number 08671629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

YASUDA Kazunori  Hokkaido Univ., School of Medicine, Professor, 医学部, 教授 (20166507)

Co-Investigator(Kenkyū-buntansha) MIYAGI Noboru  Hokkaido Univ., Hospital, Instractor, 医学部・附属病院, 助手 (90261297)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsStress deprivation / Patellar tendon / Semitendinosus tendon / Biomechanics / Autograft / In situ freezing / Mechanical properties
Research Abstract

1.The in situ freezing treatment to kill intrinsic fibroblasts significantly increased the cross-sectional area of the semitendinosus and patellar tendons. The increase ratio to the control was significantly greater in the semitendinosus tendon than in the patellar tendon. The in situ freezing treatment significantly decreased the tensile strength and the tangent modulus of the semitendinosus and patellar tendons. The decrease ratio to the control was significantly less in the semitendinosus tendon than in the patellar tendon at 3 and 6 weeks, although it was significantly greater in the former than in the latter at 12 and 24 weeks.
2.(1) Regarding the in situ frozen semitendinosus tendon, complete stress shielding significantly increased the cross-sectional area into 227% at 2 weeks ; significantly decreased the tensile strengh (control value, 75.0MP_a) into 29.9 and 17.8MP_a at 3 and 6 weeks, respectively ; and significantly decreased the tangent modulus (control value, 710.8MP_a) int … More o 425.9 and 278.1MPa at 3 and 6 weeks, respectively. Concerning the in situ frozen patellar tendon, complete stress shielding significantly increased the cross-sectional area into 167% at 2 weeks, respectively ; significantly decreased the tensile strengh (control valu, 59.5MP_a) into 14.2 and 9.8Mp_a at 3 and 6 weeks, respectively ; and significantly decreased the tangent modulus (control value, 1226MP_a) into 159 and 185MP_a at 3 and 6 weeks, respectively.
2.(2) Regarding the treated/control (T/C) ratio of the semitendinosus tendon was significantly greater than the patellar tendon at each period. The (T/C) ratio of the tangent modulus in the semitendinosus tendon was significantly greater than the that of the patellar tendon at each period. The T/Cratio of the tensile strength in semitendinosus tendon was significantly greater than the that of the patellar tendon at 1,2 and 3 weeks.
2.(3) This study demonstrated that the tissue dimension and the mechanical properties of the in situ forzen semitendinosus and patellar tendons change at a different velocity in stress-shielded environment. Less

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Majima T, et.al.: "Biomechanical effects of stress shielding of the rabbit patellar tendon depend on the degree of stress reduction." Journal of Orthopaedic Research. 14. 377-383 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohno k, et.al.: "Biomechanical and histological changes in the patellar tendon after in situ freezing." Clinical Biomechanics. 11. 207-213 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto N, et.al.: "Effects of restressing on the mechanical properties of stress-shielded patellar tendons in rabbits." Trans ASME Journal of Biomechanical Engineering. 118. 216-220 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishida H, et.al.: "Effects of resumption of loading on stress-shielded autografts after augmentation procedures. An experimental study." American Journal of Sprots Medicine. 24. 510-517 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tohyama H, et.al.: "Inhibitition of extrinsic cell infiltration prohibits reduction of the mechanical properties of the patellar tendon follownig intrinsic cell neorosis." Trans Orthop Res Soc. 21. 29-29 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsuchida T, et.al.: "Ultrastructural inhomogeneity is not reflexted in the mechanical properties in the rabbit patellar tendon." Trans Orthop Res Soc. 21. 365-365 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuda K, et.al.: "Effects of initial graft tension on clinical outcome after anterior cruciate ligament reconstruction." American Journal of Sprots Medicine. 25. 99-106 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tohyama H, et.al.: "Chronic inhibition of extrinsic cell infiltration decelerates deterioration in the mechanical properties of the patellar tendon follownig intrinsic fibroblast necrosis." Trans Orthop Res Soc. 22. 394-394 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 原 則行、他: "成熟家兎における半腱様筋腱の力学的特性の差異" 日本臨床バイオメカニクス学会誌. 17. 433-436 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 原 則行、他: "自家移植された半腱様筋腱および膝蓋腱における力学的特性の経時的変化の差" 日本整形外科学会誌. 70. S1339-S1339 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 原 則行、他: "家兎半腱様筋腱の力学的特性に及ぼすIn situ freezingの効果" 日本臨床バイオメカニクス学会誌. 18. 529-533 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 真島 任史、他: "負荷(張力)の軽減が膝前十字靭帯再建術における自家移植腱のリモデリングに与える影響" 関節外科. 16. 197-204 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuda, K: "Biomechanics. -Remodeling of tendon autograft in ligament reconstruction-" Springer-Verlag, 38 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hayashi, K: "Biomechanics. -Response of Knee joint tendons and ligaments to mechanical stress-" Springer-Verlag, 28 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Majima T,Yasuda K,Fujii T,Yamamoto N,Hayashi K,Kaneda K: "Biomechanical effects of stress shielding of the rabbit patellar tendon depend on the degree of stress reduction." J Orthop Res. 14. 377-383 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ohno K,Yasuda K,Yamamoto N,Kaneda K,Hayashi K: "Biomechanical and histological changes in the patellar tendon after in situ freezing." Clinical Biomechanicsl. 11. 207-213 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto N,Hayashi K,Kuriyama H,Ohno K,Yasuda K,Kaneda K: "Effects of restressing on the mechanical properties of stress-shielded patellar tendons in rabbits." J Biomech Eng. 118. 216-220 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishida H,Yasuda K,Hayashi K,Yamamoto N,Kaneda K: "Effects of resumption of loading on stress-shielded autografts after augmentation procedures. An experimental study." Am J Sports Med.24. 510-517 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tohyama H,Yasuda K,Miyagi N,Ohno K,Kaneda K: "Inhibitition of extrinsic cell infiltration prohibits reduction of the mechanical properties of the patellar tendon following intrinsic cell necrosis." Trans Orthop Res Soc. 21. 29 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tsuchida T,Yasuda K,Kaneda K,Hayashi K,Yamamoto N: "Ultrastructural inhomogeneity is not reflexted in the mechanical properties in the rabbit patellar tendon." Trans Orthop Res Soc. 21. 365 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuda K,Tsujino J,Tanabe Y,Kaneda K: "Effects of initial graft tension on clinical outcome after anterior cruciate ligament reconstruction." Am J Sports Med. 25. 99-106 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tohyama H,Yasuda K,Ohno K,Kaneda K: "Chronic inhibition of extrinsic cell infiltration decelerates deterioration in the mechanical properties of the patellar tendon following intrinsic fibroblast necrosis." Trans Orthop Res Soc. 22. 394 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hara N,Yasuda K,Miyagi N,Miyata K,Kimura S,Kaneda K: "Differences in the mechanical properties between the hamstring and patellar tendons in rabbits." J of Japanese Society of clinical Biomechanics. 17. 433-436 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hara N,Yasuda K,Miyata K,Kimura S,Sakai T,Miyagi N,Kaneda, K: "Differences in chronic changes of the mechanical properties between the hamstring and patellar tendon autografts. An experimental study with an in situ frozen tendon model." J Jpn Orthop Assoc. 70. S1339 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hara N,Yasuda K,Miyata K,Kimura S,Sakai T,Mikami S,Kaneda, K: "The effect of in situ freezing on the hamstring tendon of the rabbit." J of Japanese society of clinical Biomechanics. 18. 529-533 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Majima T,Yasuda K: "The effect of stress deprivation on remodeling of tendon autograft in anterior cruciate ligament reconstruction." Joint Surgery. 16. 197-204 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuda K,Hayashi K: Remodeling of tendon autograft in ligament reconstruction.In Hayashi K,Ono K,Kamiya R (Eds.) : Biomechanics. Functional adaptation and remodeling. Springer-Verlag, 213-250 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hayashi K,Yamamoto N,Yasuda K: Response of knee joint tendons and ligaments to mechanical stress.In Hayashi K,Ono K,Kamiya R (Eds.) : Biomenchanics. Functional adaptation and remodeling. Springer-Verlag, 185-212 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yasuda K, et.al.: "Effects of initial graft tension on clinical outcomc after anterior cruciate ligament reconstruction." Am J Sports Med. 25. 99-106 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tohyama H, et.al.: "Chronic inhibition of extrinsic cell infiltration deceleratea deterioration in the mechanical properties of the patellar tendon following intrinsic fibroblast necrosis." Trans Orthop Res Soc. 22. 394-394 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 原 則行, 他: "家兎半腱様筋腱の力学的特性に及ぼすIn situ freezingの効果" 日本臨床バイオメカニクス学会誌. 18. 529-533 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 真島 任史, 他: "負荷(張力)の軽減が膝前十字靱帯再建術における自家移植腱のリモデリングにあたえる影響" 関節外科. 16. 197-204 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yasuda K, et. al.: "Effects of initial graft tension on clinical outcome after anterior cruciate ligament reconstruction." Am. J. Sports Med.25. 99-106 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kimura S, et. al.: "Bioabsorbable synthetic fibers more repidly deteriorate in the bone tunnel than in the subcutaneous tissue and the intraarticulan space." Trans Orthop. Res. Soc.22. 865 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tohyama H, et al.: "Chronic inhibition of extrinsic cell infiltration decelerates deterioration in the mechanical properties of the patellar tendon following intrinsic fibroblast nearosis" Trans Orthop. Res. Soc.22. 394 (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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