• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of Exogenous Growth Factors on Ligament Healing

Research Project

Project/Area Number 08671640
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

FUKUI Naoshi (1997)  University of Tokyo, Assistant Professor, 医学部・附属病院, 助手 (10251258)

道下 和彦 (1996)  東京大学, 医学部・附属病院, 助手 (90272583)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Kozo  University of Tokyo Department of Medicine, Professor, 医学部・附属病院, 教授 (60126133)
OTDA Hiromi  University of Tokyo, Associate Professor, 医学部・附属病院, 助教授 (60101698)
福井 尚志  東京大学, 医学部・附属病院, 助手 (10251258)
Project Period (FY) 1996 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsGrowth Factor / Ligament / Healing / basic FGF / GDF-5 / bFGF / TGF / 力学試験 / PDGF / IGF / 靱帯 / procollagen mRNA
Research Abstract

In the first year of this two-year research project, we evaluated the spatial and temporal expression of the growth factors during the healing process of the medial collateral ligament (MCL) in rabbits, using a technique of immunohistochemistry.
Based on its results, we further studied the effect of exogenous growth factor on the healing process of ligaments. Firstly, we tried basic fibroblast growth factor (bFGF) to promote ligament healing. Using established model of delayed healing in rabbit's MCL, bFGF was administered using fibrin glue as a vehicle. As the result, exogenous bFGF promoted the healing of MCL to some extent, however, dosage was critical and excessive dose of bFGF might exert unfavorable effects. These results were published in Revue du Rhumatisme English Edition.
As the next step of our project, the effect of combined administration of bFGF and TGF-beta1 was studied. This study was, however, discontinued in its preliminary steps because the results were not promising.
Subsequently, we investigated the effect of growth and differentiation factor-5 (GDF-5) on ligament healing in rats. This factor is a member of TGF-beta super family, and is reported to promote ectopic formation of ligamet-like tissue. As the results of our study, this factor promotes ligament healing, based on the macroscopic, histological, biomechanical, and biochemical evaluations. This study is on its halfway now and will be completed within several months.

Report

(3 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] N.Fukui,et al.: "Effect of Local Application of Basic Fibrodast Groroth Factor on Ligament Healing in Rabbits" Rencedu Rhumatisme English Edition. 65. 406-414 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Fukui et al: "Effect of Local Application of Basic Fibroblast Growth Facloron Heament Healing in Raosts." Revue du Rhumatisme English Edition. 65. 406-414 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 福井尚志: "靭帯治癒過程における成長因子の発現について" 日本整形外科学会雑誌. 70(8). S1349 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 福井尚志: "靱帯治癒過程における成長因子の発現について" 日本整形外科学会雑誌. 70(8). S1349 (1996)

    • Related Report
      1996 Annual Research Report

URL: 

Published: 1996-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi