| Project/Area Number |
08671683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Medical Univ. |
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Principal Investigator |
YAJIMA Hiroshi Nara Medical Univ., Orthop.Surg., Lecturer, 医学部, 講師 (20221640)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAI Susumu Nara Medical Univ., Orthop.Surg., Professor, 医学部, 教授 (10075088)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | hydroxyapatite ceramics / vascularized tissue transplantation / periosteum / osteogenesis / bone marrow cells / ハイドロキシアパタイトセラミクス / 人工骨 / 異所性骨化 |
|---|
| Research Abstract |
1. We made a model of the vascularized artificial bone, combined the periosteumn with the hydroxyapatite ceramics. We evaluated that the vascularized perioteum had an osteogenic capacity using Northen blotting.
2. We evaluated the postoperative neovascularization of the hydroxyapatite ceramics using microangiogram. It was no relationship between the vascular proliferation and the osteogenic capacity.
3. We made a new model of the vascularized artificial bone with bone marrow cells. We evaluated the osteogenic capacity histologically and biochemically. We found this model had an advantage of the rapid osteogenesis postoperatively.
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